The Scripps Research Institute

Brian M Lamb

Carlos F Barbas, Iii

Thomas Gaj

Andrew Mercer

Floyd E Romesberg

Carlos F Barbas

Yorke Zhang

Carlos Barbas Iii

Carlos F Barbas Iii

Disclosed herein are methods, cells, engineered microorganisms, and kits for increased production of a nucleic acid molecule that comprises an unnatural nucleotide.

Production of unnatural nucleotides using a CRISPR/Cas9 system

Disclosed herein are chimeric polypeptides, including compositions thereof, expression vectors, and methods of use thereof, for the generation of transgenic cells, tissues, plants, and animals. The compositions, vectors, and methods of the present invention are also useful in gene therapy techniques.

Chimeric polypeptides having targeted binding specificity

Disclosed herein are chimeric polypeptides, including compositions thereof, expression vectors, and methods of use thereof, for the generation of transgenic cells, tissues, plants, and animals. The compositions, vectors, and methods of the present invention are also useful in gene therapy techniques. The invention provides a chimeric polypeptide. The polypeptide includes: a) a recombinase, nuclease or transcription factor, or fragment thereof; and b) a transcription activator-like effector (TALE) protein.

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San Diego, CA, United States of America

Brian M Lamb