G.d. Searle & Company

Brian M Bax

Daniel L Flynn

Daniel Paul Becker

Clara I Villamil

Roger A Nosal

Norman A Abood

Lori A Schretzman

Hui Li

2-Amino-benzoxazinones for the treatment of viral infections

2-amino benzoxazinones for the treatment of viral infections

A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula II ##STR1## wherein R.sup.28 is selected from (a) amino substituted with one or two radicals selected from alkyl, aralkyl, heterocycoalkyl, heterocyclo, and aryl, and (b) amino acid residues and derivatives thereof; wherein R.sup.29 is selected from hydrido, alkyl, halo, ##STR2## wherein R.sup.30 is selected from alkyl, alkoxy, alkylamino, carboxyalkyl, alkoxyalkyl, alkylaminoalkyl, cycloalkyl, heterocyclo, heterocycloalkyl, heterocycloalkoxy, alkylaminoalkoxy, alkylaminoalkylamino, heterocycloalkylamino, and N-aralkylamino; wherein R.sup.31 is alkyl; wherein R.sup.32 is alkyl and aryl; or a pharmaceutically-acceptable salt thereof.

2-amino-benzoxazinones for the treatment of viral infections

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Irvine, CA, United States of America

Brian M Bax