University of Pennsylvania

University of Illinois

Northwestern University

Tufts College

University of Washington

Georgia Tech Research Corporation

Drexel University

Brian Litt

Jonathan Viventi

Rosana Esteller

George J Vachtsevanos

John A Rogers

Dae-Hyeong Kim

Javier Ramón Echauz

David L Kaplan

Fiorenzo G Omenetto

Yonggang Huang

Jason Amsden

Javier Echauz

Ertugrul Cubukcu

Justin Blanco

Javier Ram&oacute;n Echauz

Duygu Kuzum

Yury Gogotsi

Cherie Renee Kagan

Babak Anasori

Gregory A Worrell

Dae Hyeong Kim

Drausin Wulsin

Chengyuan Wu

Emily Fox

Flavia Vitale

Kathleen Maleski

Nicolette Driscoll

Ankit N Khambhati

Steven N Baldassano

Joost Wagenaar

Jue Wu

Allan Azarion

David J Callans

Joshua D Moss

James Amsden

An electrode, the electrode including an exposed contact surface, the exposed surface comprising a contact material, the contact material comprising a MXene. A device, the device including a plurality of electrodes, each of the plurality of electrodes comprising an exposed contact surface, the exposed surface comprising a contact material, the contact material comprising a MXene. A method, the method including delivering electrical stimulation to a subject with an electrode that comprises an exposed contact surface, the exposed contact surface comprising a contact material that includes a MXene.

Implantable devices using 2D metal carbides and nitrides (MXenes)

An implantable electrode for use in the body of a subject has a metal layer and a graphene passivation layer formed on at least a portion of the metal layer. The graphene passivation layer may be a single monolayer of graphene. A process for passivating an implantable electrode is also disclosed.

Graphene-passivated implantable electrodes

Provided herein are biomedical devices and methods of making and using biomedical devices for sensing and actuation applications. For example, flexible and/or stretchable biomedical devices are provided including electronic devices useful for establishing in situ conformal contact with a tissue in a biological environment. The invention includes implantable electronic devices and devices administered to the surfaces(s) of a target tissue, for example, for obtaining electrophysiology data from a tissue such as cardiac, brain tissue or skin.

High-speed, high-resolution electrophysiology in-vivo using conformal electronics

A flexible, optically transparent electrode array comprises at least one graph electrode. The electrode may be positioned on a substrate. The flexible, optically transparent electrode may be used for simultaneous optical imaging and electrophysiological monitoring.

Transparent, flexible, low-noise electrodes for simultaneous electrophysiology and neuro-imaging

The subject matter described herein relates to methods, systems, and computer readable media for visualization of a resection target during epilepsy surgery and for real time spatiotemporal visualization of neurophysiologic biomarkers. One exemplary method includes a real time neurophysiologic biomarker visualization system implemented by at least one computer, receiving, as input, a pre-electrode-implantation MRI of an epilepsy patient's brain.

Methods, systems, and computer readable media for visualization of resection target during epilepsy surgery and for real time spatiotemporal visualization of neurophysiologic biomarkers

Provided are methods and devices for interfacing with brain tissue, specifically for monitoring and/or actuation of spatio-temporal electrical waveforms. The device is conformable having a high electrode density and high spatial and temporal resolution. A conformable substrate supports a conformable electronic circuit and a barrier layer. Electrodes are positioned to provide electrical contact with a brain tissue. A controller monitors or actuates the electrodes, thereby interfacing with the brain tissue. In an aspect, methods are provided to monitor or actuate spatio-temporal electrical waveforms over large brain surface areas by any of the devices disclosed herein.

Conformable actively multiplexed high-density surface electrode array for brain interfacing

Provided is an implantable medical device for predicting and treating electrical disturbances in tissue. The medical device includes an implantable telemetry unit (ITU), and an implantable leads assembly including a first and a second electrode implanted in the tissue. A processor of the ITU is configured to perform training by receiving electrical signals input to the electrode circuit, parsing the electrical signals into dynamic event states using Bayesian Non-Parametric Markov Switching, and modeling each event state as a multi-dimensional probability distribution. The processor of the ITU is further configured to perform analysis of the electrical signals and therapy to the tissue by applying other electrical signals to the multi-dimensional distribution to predict future electrical disturbances in the tissue, and controlling the electrode circuit to apply an electrical therapy signal to the first and second electrodes to mitigate effects of the future electrical disturbances in the tissue.

Real-time seizure prediction informed by hidden markov model event states

Provided herein are implantable biomedical devices and methods of administering implantable biomedical devices, making implantable biomedical devices, and using implantable biomedical devices to actuate a target tissue or sense a parameter associated with the target tissue in a biological environment.

Implantable biomedical devices on bioresorbable substrates

An implantable sensor array incorporates active electronic elements to greatly increase the number of sensors and their density that can be simultaneously recorded and activated. The sensors can be of various configurations and types, for example: optical, chemical, temperature, pressure or other sensors including effectors for applying signals to surrounding tissues. The sensors/effectors are arranged on a flexible and stretchable substrate with incorporated active components that allow the effective size, configuration, number and pattern of sensors/effectors to be dynamically changed, as needed, through a wired or wireless means of communication. Active processing allows many channels to be combined either through analog or digital means such that the number of wires exiting the array can be substantially reduced compared to the number of sensors/effectors on the array.

Flexible and scalable sensor arrays for recording and modulating physiological activity

Method for implanting flexible and scalable sensor arrays into patient tissues

Oscillatory signals may be used to determine a region of a patient's body that is associated with a medical condition. As described herein, oscillatory signals may be detected using a high sensitivity, low specificity detector. The oscillatory signals may be representative of discrete events in a patient's body. The detected signals may be tested in the context of surrounding background activity to identify anomalous discrete physiologic events that are sufficiently different from the surrounding background activity. The anomalous discrete physiologic events having correlative morphological, time, or location characteristics may be automatically clustered and clusters of anomalous physiologic events may be determined that are indicative of at least one region of the patient's body that is associated with a medical condition.

Method for automatic, unsupervised classification of high-frequency oscillations in physiological recordings

Flexible and scalable sensor arrays for recording and modulating physiologic activity

A sensor-effector system includes an array of sensor-effector transducers providing a plurality of sensed signals and applying a plurality of effector signals. The array provides signals to input signal conditioning circuitry which digitizes and filters the plurality of sensed signals. A processor receives the digitized signals, and processes them to generate multiple feature vectors. It also analyzes the feature vectors to identify patterns and classify the identified patterns and generates at least one response vector resulting from the recognized pattern. The response vector is applied to output signal conditioning circuitry, coupled which converts the response vector to at least one analog signal which is applied as an effector signal to the array of sensor-effector transducers.

Self-adaptive bio-signal and modulation device

Provided are methods and devices for interfacing with brain tissue, specifically for monitoring and/or actuation of spatio-temporal electrical waveforms. The device is conformable having a high electrode density and high spatial and temporal resolution. A conformable substrate supports a conformable electronic circuit and a barrier layer. Electrodes are positioned to provide electrical contact with a brain tissue. A controller monitors or actuates the electrodes, thereby interfacing with the brain tissue. In an aspect, methods are provided to monitor or actuate spatio-temporal electrical waveform over large brain surface areas by any of the devices disclosed herein.

Provided herein are implantable biomedical devices, methods of administering implantable biomedical devices, methods of making implantable biomedical devices, and methods of using implantable biomedical devices to actuate a target tissue or sense a parameter associated with the target tissue in a biological environment. Each implantable biomedical device comprises a bioresorbable substrate, an electronic device having a plurality of inorganic semiconductor components supported by the bioresorbable substrate, and a barrier layer encapsulating at least a portion of the inorganic semiconductor components. Upon contact with a biological environment the bioresorbable substrate is at least partially resorbed, thereby establishing conformal contact between the implantable biomedical device and the target tissue in the biological environment.

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Bala Cynwyd, PA, United States of America

Brian Litt