Viking Therapeutics, Inc.

Metabasis Therapeutics, Inc.

Brian Lian

Geoffrey E Barker

Hiroko Masamune

Mark D Erion

Serge H Boyer

Rochelle Hanley

Maureen Barnes

Kader Yagiz

Misha Dinerman

Erland Stevens

Hongjian Jiang

Methods useful for treating X-linked adrenoleukodystrophy are provided.

Use of thyroid beta-agonists

Disclosed herein are small molecule GIP/GLP-1 dual receptor agonist compositions, pharmaceutical compositions, the use and preparation thereof.

Compositions and methods for the treatment of metabolic and liver disorders

Disclosed herein are methods of crystallizing the compound of Formula I, as well as crystalline forms thereof. Crystalline forms of Formula I disclosed include the TBME solvate crystalline form, toluene solvate crystalline form, ethanol solvate crystalline form, THF solvate crystalline form, EtOAc solvate crystalline form, acetone solvate crystalline form and crystalline Form C.

Crystalline forms and methods of producing crystalline forms of a compound

The present disclosure is directed to methods of treating fibrotic conditions and inflammation by administration of TRβ agonists. The disclosure provides methods wherein the abnormal deposition of extracellular matrix components, such as collagen, keratin, or elastin, is reduced, either through interaction of TRβ agonists with TGF-β-dependent inflammatory pathways, or by other mechanisms, thereby ameliorating fibrotic symptoms.

Compositions for the treatment of fibrosis and inflammation

The present disclosure is directed to methods of treating fibrotic conditions by administration of TR&#x3b2; agonists. The disclosure provides methods wherein the abnormal deposition of extracellular matrix components, such as collagen, keratin, or elastin, is reduced, either through interaction of TR&#x3b2; agonists with TGF-&#x3b2;-dependent inflammatory pathways, or by other mechanisms, thereby ameliorating fibrotic symptoms.

Compositions for the treatment of fibrosis

The present disclosure provides methods and compositions for the treatment of hepatic symptoms of glycogen storage diseases through the administration of thyroid hormone receptor agonists. The methods and compositions provided herein are useful in the treatment of hyperlipidemia, hypercholesterolemia, hepatic steatosis, cardiomegaly, hepatomegaly, hepatic fibrosis, and cirrhosis associated with glycogen storage diseases (GSD) and defects of glycogen metabolism. Said compounds may also be useful in the prevention of GSD-related hepatocellular adenoma and hepatocellular carcinoma.

Growing community of inventors

San Diego, CA, United States of America

Brian Lian