American Cyanamid Company

The Procter Gamble Company

Other

Basf Aktiengesellschaft

Brian Lee Buckwalter

Thomas R LaHann

Timothy Claude Barden

Susan Mancini Cady

John Francis Chiarello

Ving J Lee

John M Janusz

Peter Bohlen

Andrew P Seddon

Hong-Ming Shieh

Michael Joseph Daley

Thomas L Cupps

Joseph H Gardner

William Wakefield Wood

John Richard Hadcock

Deborah Tardy Chaleff

Shin-Shyong Tseng

John S Logan

Gerald W Stockton

Salvatore John Cuccia

Linda Barbara Fleming

James J Takasugi

Bomi Pilloo Patel

Elizabeth F Berman

Roy Tyson Bass

Process for the preparation of chiral isofluoroenes

The present invention provides compounds of Formula I

Acaricidal and insecticidal substituted pyrimidines and a process for the preparation thereof

The present invention relates to 2-aryl-&Dgr;,-1,3,4-(oxa and thia)diazoline compounds having the structural formula

2-aryl-&Dgr;2-1,3,4-(oxa and thia)diazoline insecticidal and acaricidal agents

The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing said derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.

Stabilization of fibroblast growth factors by modification of cysteine

The present invention provides a process for the preparation of pesticidal fluoroolefin compounds having the structural formula I ##STR1## The present invention also provides intermediate compounds which are utilized in the process of this invention.

Process and intermediate compounds for the preparation of pesticidal

The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing the derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.

Stabilization of somatotropins and other proteins by modification of

Novel modified or derivatized recombinant animal somatotropins. Methods for stabilizing recombinant animal somatotropins by modification or deletion of the Cysteine residues utilizing site directed mutagenesis to replace from one to four of the cysteine amino acid residues of said somatotropins with one or more different amino acid residues or by derivatization of (1) both cysteine amino acid residues in the small loop of said somatotropin, both cysteine amino acid residues in the large loop or the four cysteine amino acid residues in both loops of said somatotropin.

Stabilization of somatotropins by modification of cysteine residues

A method for decreasing the effect of somatostatin. A peptide of formula I which is a pure somatostatin antagonist, methods for increasing the release of growth hormone, insulin and glucagon in mammals, and a method for the enhancement of growth in mammals are also described.

Pure somatostatin antagonist and methods of use thereof

The invention provides compounds of the formula: ##STR1## wherein R, R.sup.1, R.sup.2 and W are defined in the specification. These compounds are useful as antibiotic agents.

9-[(substituted

There are provided certain 13-alkyl-23-imino-LL-F28249 compounds which are useful for controlling endo- and ectoparasites, insects, acarids and nematodes.

13-alkyl-23-imino derivative of LL-F28249 compounds and their use as

There are provided certain 13-halo-23-imino-LL-F28249 compounds which are useful for controlling endo- and ectoparasites, insects, acarids and nematodes.

13-halo-23-imino derivatives of LL-F28249 compounds and their use as

Substituted phenylacetic acid amide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein X is O or S; R.sub.1 is H, OH or CH.sub.3 ; R.sub.2 is straight chain alkenyl, branched chain or cyclic hydrocarbon having from about 7 to about 24 carbon atoms; R.sub.3 is OH, OSO.sub.3.sup.-, OPO.sub.3.sup.-- or a short chain ester with from about 1 to about 6 carbon atoms.

Compounds and compositions having anti-inflammatory and analgesic

A composition, useful for producing analgesia in humans or lower animals, comprising a safe and effective amount of: an N-[(substituted pheynl)methyl]-cis-monounsaturated alkenamide pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkenamides are N-vanillyl-cis-monounsaturated alkenamides. Methods of treatment, comprising administering a safe and effective amount of these alkenamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.

Compositions and methods useful for producing analgesia

Alkadienamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein X is O or S; R is straight or branched diene having from 11 to 23 carbon atoms; R.sub.1 is H, OH, or OCH.sub.3 ; R.sub.2 is OH or a short-chain ester; and wherein at least one of R.sub.1 and R.sub.2 is OH or OCH.sub.3. Compositions, useful for producing analgesia in humans or lower animals, comprise a safe and effective amount of: an alkadienamide, pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkadienamides are N-vanillyl-alkadienamides. Methods of treatment, comprising administering a safe and effective amount of these alkadienamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.

Growing community of inventors

Yardley, PA, United States of America

Brian Lee Buckwalter