Dh Technologies Development Pte. Ltd.

Other

Brian L Williamson

Subhasish Purkayastha

Subhakar Dey

Sasi K Pillai

Michal Weinstock

Sasi Pillal

Jay D Williamson

Aaron David Williamson

Stephen J Lock

Keling Dong

Marjorie S Minkoff

Sasi Pillai

Subhakar N Dey

Fish cleaning table

A table has a table top that is fixedly attached to a support leg that forms a water pipe having an inlet and an outlet connection fitting for connecting a water supply line and a hose directly to the table so that water may flow to the hose through the leg of the table. The table may be secured to an edge of a dock over water using a bracket. The table top may be cleaned with water spray directly from the hose. Rear support legs of the table may form hollow tubes each having an upper open end and a lower open end at opposing ends of the tube. Each upper open end is defined by an opening on the top side of the table top. When hosing the table after cleaning fish, blood and other remains of fish may be flushed down through the tubes directly into the water below.

A table that may be used for cleaning fish has a table top that is fixedly attached to front and rear support legs. The rear support legs form hollow tubes each having an upper open end and a lower open end at opposing ends of the tube. The upper open end is defined by an opening on the top side of the table top. The support legs have a bracket attached to the lower ends of the legs for securing the table to an edge of a dock that is over water. When cleaning fish, the table top may be cleaned with water spray from a hose by flushing blood and other remains of cleaned fish down through the tubes and into the water below. The tubes within the support legs provide a conduit through which blood and other fish remains may be discharged directly into the water.

Canopy frame

Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids and includes testosterone. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry.

Specific analysis of ketone and aldehyde analytes using reagent compounds, labeling strategies, and mass spectrometry workflow

Methods and systems for detecting allergens using mass spectrometry are provided herein. In some aspects, a sample can be screened for the presence or quantity of ovalbumin, lysozyme, casein (isoform S1 and S2), lactoglobulin, high and low glutens, wheat, rye, oats, barley, mustard, sesame, and various types of nuts including macadamia, pistachio, brazil, walnuts, peanuts and hazelnuts by detecting one or more peptides specific to the allergen of interest using selected MRM transitions.

System and method for the detection of allergens

A method for screening a drug for cytochrome P450 (CYP) induction is provided and can include incubating the drug with a microsome-containing biological sample and then quantitating at least one cytochrome P450 isoform. The isoforms can be selected from 2B6, 3A4, 1A2, and 3A5 isoforms. In some embodiments, the method uses liquid chromatography tandem mass spectrometry (LC-MSMS). A quantitated value can be compared to a threshold value and the drug can be determined to exhibit an acceptable CYP induction potential when the quantitated value does not exceed the threshold value. Isolated peptides are also provided.

Mass spectrometry quantitation of P450 isoforms in hepatocytes

Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry.

A composition, method, and kit for calibrating a mass spectrometer including a predetermined concentration of a calibrant having a mixture of amino acid polyethylene glycol compounds and a solvent for dissolving the calibrant. The calibrant can be used in either positive or negative ionization mode, and it can be used in calibrating an atmospheric pressure chemical ionization or an electrospray mass spectrometer. The calibrant can include a mixture to enable calibration across a broad range of masses.

Composition, method, and kit for calibrating a mass spectrometer

Quantification of vitamin D2, vitamin D3, and the monohydroxy and diihydroxy metabolites of vitamin D2 and vitamin D3, can comprise labeling analytes with mass spectrometry (MS) tagging reagents and performing LC-MSMS analysis of the labeled analytes. The labeled analytes can include a labeled standard and can have distinct retention times on a reversed phase column, as well as distinct masses. Under high energy collisions, reporter groups can be generated. The intensity or the peak area detected for each reporter group can be used for quantitation. In some embodiments, a one-step tagging reagent is used that is a dienophile-containing, labeled m Diels Alder reagent.

Quantitative analysis of vitamin D3, vitamin D2, and metabolites thereof

Quantification of vitamin D2, vitamin D3, and the monohydroxy and diihydroxy metabolites of vitamin D2 and vitamin D3, can comprise labeling analytes with mass spectrometry (MS) tagging reagents and performing LC-MSMS analysis of the labeled analytes. The labeled analytes can include a labeled standard and can have distinct retention times on a reversed phase column, as well as distinct masses. Under high energy collisions, reporter groups can be generated. The intensity or the peak area detected for each reporter group can be used for quantitation. In some embodiments, a one-step tagging reagent is used that is a dienophile-containing, labeled Diels Alder reagent.

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Ashland, MA, United States of America

Brian L Williamson