Coherex Medical, Inc.

Brian K Whisenant

Scott D Miles

Clark C Davis

Richard J Linder

Daryl Edmiston

DeWayne C Fox

David L Stott

Randall K Jones

Several embodiments are set forth of devices, systems and methods for modifying an atrial appendage such as a left atrial appendage (LAA). In one embodiment, a medical device includes a frame member and a tissue growth member. The frame member includes a unitary, seamless central portion having a plurality of struts defining a multi-cellular structure and an anchoring system, the plurality of struts extending between and configured to self-expand and directly bias the anchor system to anchor the frame member at least partially within the LAA. With this arrangement, the tissue growth member is attached to the frame member to occlude the LAA.

Medical device for modification of left atrial appendage and related systems and methods

A method and system are provided for percutaneously gaining access to oxygenated blood with one or more anastomosis devices and pumping such oxygenated blood directly to the aorta adjacent to the right atrium or left atrium via a VAD system. In one embodiment, a VAD system can be implanted with open surgery.

Ventricular assist device and related methods

A medical device, system and method for modifying a left atrial appendage ('LAA'). The medical device system includes a tether anchored within the LAA and one or more tissue growth members or occluders configured to be slid over the tether and lodged within the LAA. With this arrangement, a physician may close-off the LAA with a selective number of tissue growth members to meet the varying LAA sizes as determined from imaging information while conducting the procedure.

Several embodiments are set forth of devices, systems and methods for modifying an atrial appendage such as a left atrial appendage (LAA). In one embodiment, a device includes a body that is collapsible and self-expanding. The body includes a textured surface with protruding portions and recessed portions. The body may be formed of a reticulated foam material and may exhibit a substantially spherical geometry or a truncated spherical geometry. The body may be substantially hollow. In one embodiment, portions of the textured surface may be metalized or have a coating placed thereon to enhance frictional engagement of the body with the atrial appendage wall. In another embodiment, a mesh bag is disposed within an LAA and one or more self-expanding bodies are disposed within the mesh bag. The mesh bag is then secured to retain the self-expanding bodies within the bag and the LAA.

A method and system are provided for percutaneously gaining access to oxygenated bood with an anastomosis device and pumping such oxygenated blood to other arterial regions of the vascular system. In one embodiment, a system may include an anastomosis device extending through an opening of the atrial septum. A filament may be coupled to the anastomosis device. A snare may access the right atrium through the superior vena cava, grasp the filament, and withdraw the filament through the superior vena cava. The filament may then be used as a guide to direct a catheter, a conduit or some other structure into the right atrium of the heart via the superior vena cava. A flow path may be defined between the anastomosis device and an arterial location, such as in the aorta, such that at least some oxygenated blood may by-pass the left ventricle and be discharged into the aorta.

A medical device for reducing the size of a Patent Foramen Ovale is disclosed. The medical device can include a first electrode, a second electrode, and at least one sensor mounted to at least one of the first electrode or the second electrode, the at least one sensor adapted to sense at least one operating parameter of the medical device or the patient to facilitate closure of the Patent Foramen Ovale. The medical device can also include a delivery shaft coupled to the first electrode, wherein the delivery shaft includes an indicia for determining the position of the first electrode relative to the second electrode. A method for determining a characteristic of an internal tissue opening is also disclosed. The method can include the steps of introducing a detectable fluid in the right atrium of a heart and then detecting the location of the detectable fluid in the heart.

Methods, systems, and devices for sensing, measuring, and controlling closure of a patent foramen ovale

A method and system are provided for percutaneously gaining access to oxygenated blood with an anastomosis device and pumping such oxygenated blood to other arterial regions of the vascular system via an LVAD system. In one embodiment, a system may include an anastomosis device extending through an opening of the atrial septum. A filament may be coupled to the anastomosis device. A snare device may access the right atrium through the superior vena cava, grasp the filament, and withdraw the filament through the superior vena cava. The filament may then be used as a guide to direct a catheter, a conduit or some other structure into the right atrium of the heart via the superior vena cava. A flow path may be defined between the anastomosis device and an arterial location, such as in the aorta, such that at least some oxygenated blood may by-pass the left ventricle and be discharged into the aorta.

A medical system and device for use in delivering RF energy to a tissue opening and a method for determining an RF dose is disclosed. In one embodiment, the medical device includes an electrode or anchor and one or more devices, such as an impedance electrode, RF electrode and/or thermocouple. The electrode or anchor can be deployed from a delivery shaft inside the left atrium, for example, of a heart and substantially conform to the tissue proximate the tissue opening. Tissue characteristics, such as temperature and/or impedance, can be measured, before, during and after application of RF energy to the tissue, by one or more devices to determine an RF dose. After energy is applied to the tissue between the left and right electrodes, the left electrode can be removed from the left atrium by being received back into the delivery shaft and the delivery shaft thereafter removed from the opening.

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Salt Lake City, UT, United States of America

Brian K Whisenant