General Electric Company

Bl Technologies, Inc.

Ge Analytical Instruments

Brian K Clay

Matthew Kaddeland Stonesmith

Gordon K Francis

F Allen Dettling

Thomas D Szakas

Richard D Godec

Martin B Tobias

Stan Needle

Krzysztof Franaszczuk

Helen Prieto Martinez

Larry Macklin

Steve Poirier

Verification plates for a bacterial endotoxin reader are provided, namely a temperature verification plate (TVP) and optical verification plate (OVP). The TVP has a body configured to be placed on a spindle of said reader and rotated by said spindle. The body has a temperature verification circuit with a temperature sensor and a temperature indicator. The temperature sensor is configured to measure a temperature of the body rotated by the spindle of the reader. The temperature indicator optically represents a value of the temperature measured by the temperature sensor. The temperature indicator is readable by an optical bench of the reader. The OVP has a body with a plurality of apertures located along a periphery that line up with an optical bench of the reader. Light produced by a light source of the reader can pass through the aperture and an intensity measured by a photodetector of the reader.

Bacterial endotoxin reader verification plates and methods of use

A flow sensor circuit for a fluid flowpath having a self-heated thermistor situated in a fluid flowpath. The flow sensor circuit is configured to energize the thermistor sufficiently to heat the thermistor, calculate the slope of the leading edge of the rise in temperature of the thermistor when the thermistor is energized, and equate the slope to the state of the fluid flowing through the fluid flowpath. In another embodiment, the flow sensor circuit is configured to energize the thermistor, measure and calculate the average and standard deviation of the thermistor temperature, and determine the state of the flowpath using the thermistor temperature average and standard deviation.

Flow sensor circuit for monitoring a fluid flowpath

The stirring apparatus is an electronic design that generates rotating magnetic fields to drive magnetic stir bars within vials placed above the cover of the stirring apparatus. Below the cover is a magnetics board containing multiple vial groups of four air core coils arranged in rectangular patterns. Each vial group has with two pairs of diagonal coils. The coils in each pair are wired in series and have opposite winding directions. Each pair is driven by a different phase of a stepper motor driver. The vial groups are spaced appropriately for placing one vial above each group. The adjacent coils of adjacent vial groups are driven by the same phase and have the same magnetic direction. The cover contains an array of pole standoffs that matches the coil pattern. The hollow center of each air core coil contains at least a portion of one pole standoff.

Electromagnetic stirring apparatus

Apparatuses and systems for sampling fluid and providing fluid to an analyzer are provided. In an embodiment, a sampler may have a state switch for the housing cover. In another embodiment, multiple fluid streams may be housed in a single housing.

Apparatus and system for sampling and supplying a fluid to an analyzer

An automated standards sampling apparatus () and method for using such, apparatus are described. The apparatus can be integrated with a liquid analyzer to form a compact, integrated liquid analysis unit. When used in combination with a specially adapted vial se of standard liquids, the apparatus provides a system for automated, substantially error-free periodic calibration and accuracy verification for an online TOC analyzer (). The automated standards sampling apparatus of this invention facilitates the easy introduction of known concentrations of standard solutions and 'grab' samples into online TOC analyzers to satisfy regulatory compliance, calibration, and validation requirements. The automated standards sampling apparatus of this invention also provides substantially improved reliability, higher productivity and better performance when running the critical and regulatory driven System Suitability Test than does any conventional sampling equipment, and it is likely to find wide use in a variety of industrial applications other than its principal intended use in the pharmaceutical industry.

Automated standards sampling

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Westminster, CO, United States of America

Brian K Clay