Powderject Research Limited

Other

National Research Development Corporation

Bellhouse Technology Limited

Isis Innovation Limited

Oxford Biosciences Limited

Bellhouse Medical Products Limited

Brian John Bellhouse

John Christopher Greenford

David Francis Sarphie

John Bell

Sydney M Pugh

Charles David Potter

William S Haworth

Colin David Sheldrake

Francis H Bellhouse

Paul Rudd Drayson

Maxwell R Derrick

Stuart G Weekes

David Stuart Potter

George Costigan

Fiona Carter

William G Williams

Huw Richard Millward

John W Stairmand

Monisha Jane Phillips

Charles David Ogilvy Potter

Samih M Nabulsi

Stephen Goodman

Ian J Sobey

A needleless syringe having a membrane () which is ruptured by gas pressure to generate a supersonic gas flow in which particles containing a therapeutic agent are injected.

Needleless syringe using supersonic gas flow for particle delivery

A method of distributing particles in a flow of gas and a needleless syringe for use in the needleless injection of particles into the skin or mucosa of a vertebrate subject are disclosed. The syringe includes a convergence which reduces pressure of the gas flowing in the gas flow path due to the Venturi effect such that particles initially located outside of the gas flow path are drawn into the gas flow path under the action of the reduced pressure and become entrained in the gas. An exit nozzle accelerates the particles so entrained. In another aspect of the invention, there is provided a method of creating a gas flow in a needleless syringe which comprises flowing gas through a first convergence into a chamber to form a transsonic gas jet in the chamber and passing the gas jet from the chamber into a second convergence and along the nozzle.

Needleless syringe

A needleless syringe particle delivery system is provided. The needleless syringe has an elongate nozzle that is connected at its upstream end to a sealed chamber. The sealed chamber contains gas at super-atmospheric pressure and particles of a therapeutic agent. Upon release of the gas from the sealed chamber, a flow is formed which entrains the particles and allows the particles to pass through the nozzle at supersonic speed for subsequent delivery to a target surface.

Particle delivery

A syringe, for use in the delivery of a dose of a therapeutic agent entrained within a pressurized fluid flow, includes an upstream portion, an intermediate portion, a downstream portion, and an actuator mechanism for initiating a flow of the fluid through the syringe. The upstream portion is interfaced with a source of fluid under pressure. The intermediate portion, which is interposed between the upstream and downstream portions, includes first and second members that are coupled together to provide a closed pocket for containing the dose. One of the first and second members is moveable relative to the other within the syringe to provide an open configuration in which the pocket is opened to expose the dose for entrainment by the fluid as it flows through the intermediate portion and to and through the nozzle. Also provided is a capsule formed from the first and second members.

Syringe and capsule therefor

Needleless syringe using super sonic gas flow for particle delivery

A needleless syringe comprising a body containing a lumen, an upstream end of which is, or is arranged to be, connected to a source of gaseous pressure which can suddenly be released into the lumen; the downstream end of the lumen terminating behind a bistable diaphragm which is movable between an inverted position in which it presents outwardly of the body a concavity for containing particles of a therapeutic agent, and an everted, outwardly convex, position; the arrangement being such that, in use, when gas under pressure is released into the lumen, the diaphragm will snap over from its inverted to its everted position and catapult the particles outwardly.

A needleless syringe capable of accelerating particles into a target surface is provided. The syringe comprises a body having a lumen with a diaphragm located adjacent to a terminus thereof. Particles are delivered from an external surface of the diaphragm by means of the motive force provided by the impact of a shockwave imparted to the internal surface of the diaphragm. A method for delivering particles from the needleless syringe is also provided.

A membrane filter having one or more ducts is disclosed herein. Each of the ducts has a porous wall defining a lumen surrounded by helical grooves in the respective wall. The groove can be a single, double, or triple start groove defining a flow direction along the groove. The cross sectional area of the groove in the case of a single start groove, or aggregate cross sectional area of the groove in the case of a double or triple start groove, perpendicular to the flow direction along the lumen is within a range of 75% to 125% of the cross sectional area of the lumen. The helical grooves create vortices which reduce concentration polarization while increasing membrane area.

Filter comprising one or more ducts

A needleless syringe having a membrane (,) which is ruptured by gas pressure to generate a supersonic gas flow in which particles containing a therapeutic agent are injected.

A needleless syringe particle delivery system is provided. The needleless syringe comprises an elongate nozzle which is connected at its upstream end to an open ended capsule chamber. The capsule chamber is configured to house and intimately enclose a nonrigid capsule containing particles of a therapeutic agent. An opening means is provided at the upstream end of the capsule chamber, and is used to pierce the upstream end of a capsule in the chamber. After the capsule is opened, an energizing means connected to the upstream end of the capsule chamber applies a gaseous pressure sufficient to force the particles out of the capsule and the open downstream end of the capsule chamber and thus to create through the nozzle a supersonic gas flow in which the particles are entrained.

A needleless syringe capable of accelerating particles comprising a therapeutic agent across skin or mucosal tissue of a vertebrate subject is provided. The syringe comprises an elongate tubular nozzle having a bend along its length and is connected to or capable of connection to a suitable energizing means for producing in the nozzle a supersonic condition sufficient to cause delivery of the particles to a target surface. A method for delivering particles comprising a therapeutic agent from the needleless syringe is also provided.

Trans-mucosal particle delivery

A needleless syringe, in which particles of a therapeutic agent are entrained in a high pressure gas flow, has a nozzle surrounded by a shroud silencer through which gas reflected from the target surface may be vented to atmosphere while retaining any particles reflected in the gas.

A needleless syringe having a membrane which is ruptured by gas pressure to generate a supersonic gas flow in which particles containing a therapeutic agent are injected.

A needleless syringe having a membrane which is ruptured by gas pressure to generate a supersonic gas flow in which particles containing a therapeutic agent are injected. This provides effective transdermal delivery of the therapeutic agent.

Growing community of inventors

Islip, United Kingdom

Brian John Bellhouse