Roche Diagnostics Hematology, Inc.

Becton Dickinson and Company Limited

Qiagen Gaithersburg Inc.

Confluent Photonics Corporation

Constitution Medical, Inc.

Brian James McKeen

Eric Yeaton

David J Zahniser

Dennis P Poole

Daniel C Lapen

Mark J Licari

James L Dowling

Stephen Conroy

Dwight Livingston

Michael T VanSickler

Steven Charles Rotundo

Kevin Bailey

Stephen Robert LaChance

Gerard J Sevigny

Christopher John Tesluk

Michael J Touma

Thomas A Schaefer

Gregory G Cappiello

Robert C Aviles

Ninghui Zhu

Andrew J Radl

Mark Anthony Messina

William John Hubbard

Kevin J McIntyre

Dick Rolfe

Gerard Sevigny

Paul Ouellette

Evgueni V Babenko

Kurt E Abdelmaseh

Michael Touma

Ted Carl Edens

The apparatus disclosed herein features a substrate arm and gripper, a platform having a top surface located opposite the substrate when the substrate arm is in a specimen processing position and featuring at least one fluid port located on a surface of the platform facing the substrate and at least one vacuum port located on the surface of the platform facing the substrate, and during operation, the apparatus is configured to (a) dispense a first quantity of fluid from the at least one fluid port to fill a separation between the substrate and the platform, (b) dispense an additional quantity of fluid from the at least one fluid port into the separation to displace a portion of the first quantity of fluid, and (c) remove the portion of the first quantity of fluid from the separation through the at least one vacuum port.

Automated systems and methods for preparing biological specimens for examination

An automated pre-analytical processing method and an apparatus for pre-analytical processing of samples to be forwarded to an adjacent analyzer for analysis. Rack label information is read and communicated to a processor. From the rack label information, the processor determines where to route the rack. The pre-analytical system has a rack robot that conveys racks to discrete locations depending upon the routing information assigned to the rack by the processor. The pre-analytical system has an automated station that reads the labels of individual sample containers in the rack that are brought to the automated station on instructions from the processor. Depending on the type of sample container and the type of sample disposed therein, the samples are either prepared for analysis by the automated station or the sample containers are directly passed through the automated station. Prepared samples and passed through samples are passed individually to a batching rack.

Automated sample preparation system for diagnostic testing of same

The systems and methods disclosed herein permit automated preparation of biological specimens for examination. The disclosed systems and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids. The methods include at least a fixing phase for fixing a biological specimen to a substrate such as a microscope slide, a staining phase for staining the specimen, and a rinsing phase for rinsing the specimen. One or more of the fixing, staining, and rinsing phases include one or more agitation cycles for distributing reagents evenly and uniformly across the specimen. The systems can be implemented as a standalone device or as a component in a larger system for preparing and examining biological specimens.

Sample application systems can include an extraction mechanism to remove a sample from sample containers, a sample vessel disposed on a deployment mechanism, where the deployment mechanism is arranged to move the sample vessel to receive a sample, an extraction mechanism washing station to wash the extraction mechanism, a sample applicator to remove a portion of the sample in the sample vessel and apply it onto a sample carrier, where the deployment mechanism can move the sample vessel to a sample application position, a sample vessel washing station to wash the sample vessel, where the deployment mechanism can move the sample vessel to the sample vessel washing station, a sample applicator washing station to wash the sample applicator after the sample has been dispensed onto the sample carrier, and a fluid control system to control flow of a fluid provided to the extraction mechanism and the sample applicator.

Fluid sample preparation systems and methods

Sample transport systems are described that move a sample carrier from one station to a next station in a sample processing systems. The systems include: a translating member; two or more sample carrier retaining devices attached to the translating member, wherein each of the two or more sample carrier retaining devices can include a retainer portion to temporarily retain one or more sample carriers; and a movement mechanism to move the translating member and the attached sample carrier retaining devices between a first position and a second position; wherein the sample carrier retaining devices are controlled and moved simultaneously to retain a sample carrier when the translating member reaches the first position and to release a sample carrier when the translating member reaches the second position to successively advance sample carriers in the sample processing systems.

Sample transport systems and methods

A system and method for automated handling of vials containing liquid medical specimens is disclosed. The robotic system processes the specimens for further downstream molecular analysis. The processing comprises automated vial cap removal, pipetting of the vial contents, transfer of the vial contents to a destination tray such as a multiwell plate, and recapping of the vial.

Sample preparation system and method for processing clinical specimens

An opto-mechanical platform for supporting truncated optical elements having at least one substantially flat side surface is disclosed. In one particular exemplary embodiment, the opto-mechanical platform may be realized as an apparatus for supporting truncated optical elements having at least one substantially flat side surface. Such an apparatus may comprise a platform having a substantially flat surface area for supporting the substantially flat side surface of the truncated optical elements. Such an apparatus may also comprise at least one substantially vertical wall formed on at least a portion of the platform for providing mechanical rigidity to the platform.

Opto-mechanical platform

Growing community of inventors

Bow, NH, United States of America

Brian James McKeen