Leland Stanford Junior University

Brian Hsueh

Karl A Deisseroth

John Eric Paderi

Brian T Kannard

Ritu Lal

Peter Luke Santa Maria

Abhinav Ramani

William E Allen

Li Ye

Peter Santa Maria

Brian Kannard

The present disclosure provides methods of preparing a biological specimen for imaging analysis, comprising fixing and clearing the biological specimen and subsequently analyzing the cleared biological specimen using microscopy. Also included are methods of quantifying cells, for example, active populations of cells in response to a stimulant. The present disclosure also provides devices for practicing the described methods. A flow-assisted clearing device provides rapid clearing of hydrogel-embedded biological specimens without the need of specialized equipment such as electrophoresis or perfusion devices.

Method and system for imaging and analysis of a biological specimen

A method for maintaining and/or increasing body temperature of a patient may involve delivering heat to a first location on a limb of the patient, delivering heat to a second location on the limb, apart from the first location, and applying intermittent compression to a third location on the limb, located between the first location and the second location. A device for maintaining and/or increasing body temperature of a patient may include a sleeve for positioning over at least part of one of the patient's limbs, first and second heat delivery members coupled with the sleeve, and an intermittent compression member coupled with the sleeve between the first and second heat delivery members.

Method and system for regulating core body temperature

Growing community of inventors

Pacifica, CA, United States of America

Brian Hsueh