Novartis Ag

Brian Holmberg

Lu Huang

Tony Fleming

Aida Abujoub

Connie Hong

John Blankenship

Chonghui Zhang

Dexiu Bu

Haihui Lu

Jennifer Brogdon

Glenn Dranoff

Boris Engels

Brian Walter Granda

Carla Guimaraes

Xu Zhu

Michael R Greene

Andrew Marc Stein

Akash Sohoni

Attilio Bondanza

Olja Kodrasi

Elizabeth Dorothy Pratico

Hyungwook Lim

Serena De Vita

Anniesha Hack

Joni Waiee Lam

Andrew Price

Louise Treanor

The invention provides immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions and methods thereof.

Chimeric antigen receptors and uses thereof

The present disclosure provides BCMA binding molecules that specifically bind to human BCMA, conjugates comprising the BCMA binding molecules, and pharmaceutical compositions comprising the BCMA binding molecules and the conjugates. The disclosure further provides methods of using the BCMA binding molecules to treat cancers that express cell surface BCMA. The disclosure yet further provides recombinant host cells engineered to express the BCMA binding molecules and methods of producing the BCMA binding molecules by culturing the host cells under conditions in which the BCMA binding molecules are expressed.

Binding molecules against BCMA and uses thereof

The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

BCMA chimeric antigen receptors and uses thereof

Growing community of inventors

Somerville, MA, United States of America

Brian Holmberg