Zimmer Gmbh

Stryker Sustainability Solutions, Inc.

Zimmer Technology, Inc.

Brian H Thomas

Donald L Yakimicki

Kai Zhang

Steven Charlebois

Oludele O Popoola

Norman Stark

Ray Gsell

Jeffrey P Anderson

Dean Acker

Ed Cantey

Orhun K Muratoglu

Robert A Hodorek

Niels Alexander Abt

Stephen H Spiegelberg

Robert Garryl Hudgins

Jerry L Lower

James Mason

Luis Diaz

Miguel J Gonzalez

Dan Peterson

Dan Fowler

Jody Berkey

Jose Vasquez

Gareth H McKinley

Michael E Hawkins

Russell M Parrott

Dirk Pletcher

Joseph R Vargas

Steven Seelman

Hallie E Brinkerhuff

Matthew L Mroczkowski

David M Miller

Lynn A Kirkpatrick

Gavin Braithwaite

Michael Wallick

Kimberly Mimnaugh

Thorsten Schwenke

Kaifeng Liu

David Miller

Donald Yakimicki

Laura L Borgstede

Garryl Hudgins

Seth Gilchrist

Maria S Streckenbach

Oludele Popoola

Maria Streckenbach

Hallie Brinkerhuff

An apparatus for cleaning an instrument with a cleaning fluid includes a vessel defining a chamber and a port for at least partially filling the chamber with the fluid. The apparatus further includes an ultrasonic transducer for delivering ultrasonic energy to the fluid, and a vacuum pump for depressurizing the chamber. The apparatus further includes a rotatable device removably disposable in the chamber and having a rack defining a cavity for supporting the instrument. The rotatable device also has a fluid delivery member extending toward the cavity and having a fluid channel between an inlet and an outlet. The apparatus further includes a fluid transmission system in fluid communication with the chamber and the fluid channel of the fluid delivery member for circulating the fluid from the chamber through the fluid channel of the fluid delivery member. A method of cleaning an instrument is also provided.

Apparatus and method for cleaning an instrument

Polymer compositions having one or more antioxidants providing high crosslink density and improved oxidation resistance to the polymer composition and methods for making same. Such polymer compositions can be used to make orthopedic implants.

Crosslinked polymers including one or more antioxidants, methods for making same and methods for selecting antioxidants

A prosthetic glenoid component for replicating the behavior of a patient's natural glenoid includes a rim that replicates the patient's natural glenoid labrum.

Glenoid implant with synthetic labrum

The present disclosure is directed to polymer compositions having one or more antioxidants providing high crosslink density and improved oxidation resistance to the polymer composition and methods for making same. Such polymer compositions can be advantageously used to make orthopedic implants. The disclosure also provides methods for selecting antioxidants providing desirable properties to the polymer composition. In one embodiment, a measure of OIT can be used to select the antioxidant and antioxidant blend. In another embodiment, measurements of OIT and OI-rate can be used to select the one or more antioxidants. In an other embodiment, the product of OIT and crosslink density can be calculated to predict wear resistance and oxidation resistance of a polymer composition including one or more antioxidants.

Various embodiments of mosaicplasty constructs and methods for implanting the constructs into anatomical structures. The mosaicplasty constructs may be formed from artificial materials and may include a hard articulating portion and a relatively softer elastic, support portion. The mosaicplasty constructs may include bone ingrowth materials to facilitate ingrowth of bone and other tissues into the construct. The mosaicplasty constructs may also be at least partially formed of hydrogel materials.

Mosaicplasty constructs

Monoblock orthopedic and/or dental implants are disclosed. The monoblock implants include a ceramic articulating surface and an osseointegrative bone-contacting surface. Methods of making such implants also disclosed.

Ceramic monoblock implants with osseointegration fixation surfaces

An orthopedic implant including an articulation portion having a pyrolytic carbon bearing surface and a porous bone on- or in-growth structure, and methods of making the same.

Pyrolytic carbon implants with porous fixation component and methods of making the same

A synthetic polymer based adhesive formulation that has properties substantially simulating selected properties of fibrin glue, and methods of making and using the same. The adhesive formulation includes a discrete acid solution and discrete base solution that when combined form a synthetic polymer based adhesive that substantially simulates selected properties of fibrin glue. The discrete acid solution includes a polymer and a cross-linking agent precursor. The discrete base solution includes a polymer and a base.

Synthetic polymer adhesives and methods for making, using and delivering the same

Methods of forming polymeric articles using plasma treated polymer resins, and orthopedic implants comprising a polymeric article wherein the polymeric article has reactive groups bonded to polymer molecules in an interior region of the polymeric article.

Modified polymeric materials and methods of modifying polymeric materials

The present invention relates to polymers and, specifically, to surface modification of polymers. In one exemplary embodiment, the present invention increases the bond strength of UHMWPE components to PMMA bone cement by creating a chemical bond between the UHMWPE components and the PMMA bone cement. Specifically, in one exemplary embodiment, a surface of the UHMWPE component that is to be bonded to PMMA bone cement is treated with an oxidizing agent, such as an aqueous solution of hydrogen peroxide. In one exemplary embodiment, the UHMWPE component is treated with hydrogen peroxide by swabbing the surface of the UHMWPE component with the hydrogen peroxide solution. The surface of the UHMWPE component may then be dried and PMMA bone cement applied to the surface of the UHMWPE component.

Surface modification of ultrahigh molecular weight polyethylene

Artificial or synthetic synovial fluids and methods for making such fluids are disclosed. The fluid includes selected proteins, phospholipids and hyaluronic acid and mimics the properties of human synovial fluid.

Synthetic synovial fluid compositions and methods for making the same

This invention provides methods and processes to attach or bond hydrogels to suitable surfaces using irradiation techniques and also provides methods and processes to create crosslinked regions in hydrogel articles using these irradiation techniques. Specifically, lasers at wavelengths tuned to the irradiation absorption bands of hydroxyl groups, carboxylic acid groups or water may be used to attach or bond hydrogels to surfaces such as soft tissue and hydrogel surfaces or to crosslink regions in hydrogel articles.

Methods of bonding or modifying hydrogels using irradiation

The invention provides a multi-polymer hydrogel article having a first polymeric, water-swellable material and a second polymeric material, organized such that a first region substantially comprises the first polymeric, water-swellable material, a second region adjacent the first region comprises a mixture of the first polymeric, water-swellable material and the second polymeric material, and a third region adjacent the second region substantially comprises the second polymeric material. The article exhibits an increasing concentration gradient of the second polymeric material moving from the first region, through the second region, to the third region. The invention also provides methods for forming a multi-polymer hydrogel article by (a) forming a hydrogel structure using a first polymeric, water-swellable material, (b) creating an aerogel structure having a plurality of open pores by dehydrating the hydrogel structure, (c) contacting the aerogel structure with a second polymeric material to incorporate the second polymeric material into at least a portion of the plurality of open pores to form the multi-polymer hydrogel article, and (d) rehydrating the multi-polymer hydrogel article.

Multi-polymer hydrogels

The present invention provides hydrogel coated, implantable medical devices and methods of coating hydrogels onto implantable medical devices. In one embodiment, a hydrogel coated medical device is formed by physically treating a surface of the medical device, chemically treating the surface, applying a hydrogel precursor and then crosslinking the hydrogel precursor to form a hydrogel coating on the surface of the medical device. The present invention may be particularly applicable for coating articulating surfaces on implantable medical devices such as artificial joints.

Methods of preparing hydrogel coatings

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Columbia City, IN, United States of America

Brian H Thomas