King's College London

Other

Proteome Sciences Plc

Brian H Anderton

Malcolm Andrew Ward

Helen Louise Byers

Pascal Derkinderen

Christopher Hugh Reynolds

Ritchie Williamson

Diane Hanger

Christopher C Miller

Methods for screening for substances capable of modulating the phosphorylation of tau protein are disclosed, and in particular paired helical filament (PHF) tau, and the use of such modulators in the treatment of tauopathies. The assays and screening methods are based on the identification of new phosphorylation sites in PHF tau and new kinases and combinations of kinases as therapeutic targets, in particular the identification of casein kinase 1 as a kinase which phosphorylates tau protein.

Methods for screening for inhibitors of tau phosphorylation by casein kinase I

The present invention provides methods of screening for candidate compounds useful in the treatment of Alzheimer's disease and related conditions by inhibiting specific phosphorylation of tau protein by tyrosine kinase c-Abl.

Method of screening for inhibitors of tau protein phosphororylation by tyrosine kinase c-Abl

Models of Alzheimer's disease

Growing community of inventors

London, United Kingdom

Brian H Anderton