Karl Thomae Gmbh

Dr. Karl Thomae Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Boehringer Ingelheim Pharma Kg

Boehringer Ingelheim Vetmedica Gmbh

Brian Guth

Volkhard Austel

Helmut Pieper

Johannes M Weisenberger

Frank Himmelsbach

Gunter Linz

Thomas Muller

F Himmelsbach

Juergen Daemmgen

Randolph Seidler

Thomas M Uller

G Unter Linz

Hans-Dieter Schubert

Gunther Linz

The present invention provides the use in a pharmaceutical composition of a specific cyclic amine derivative, or its pharmaceutically acceptable salts, for the treatment of heart failure of any aetiology.

Use of a specific cyclic amine derivative or the pharmaceutically acceptable salts thereof for the treatment or prevention of heart failure

The present invention relates to the new use of bradycardiac substances such as a Cachannel blocker, beta-receptor blocker or ichannel blocker, the ichannel blockers being preferred, optionally in combination with a cardioactive substance for inducing the regression of myocardial diseases accompanied by hypertrophy, particularly for the treatment of idiopathic hypertrophic cardiomyopathies (HCM) in humans and domestic pets.

Use of bradycardiac substances in the treatment of myocardial diseases associated with hypertrophy and novel medicament combinations

The present invention relates to phenylamidines of general formulawherein

Substituted phenylamidines medicaments containing said compounds and method for production thereof

Substituted phenylamidines

The present invention relates to carboxylic acid derivatives of the general formula ##STR1## in which R.sub.a to R.sub.c, A, B, D, E and X.sub.1 to X.sub.3 are as defined in claim 1, their tautomers, their stereoisomers including their mixtures, and their salts, in particular their physiologically tolerated salts with inorganic or organic acids or bases, which have useful pharmacological properties, preferably aggregation-inhibiting inhibiting actions, medicaments containing these compounds, their use and processes for their preparation.

Carboxylic acid derivatives, medicaments comprising these compounds,

Substituted phenylamindines, medicaments containing these compounds and

The present invention relates to piperazine derivatives of the general formula ##STR1## in which R.sub.a, Y.sub.1 to Y.sub.3 and E are defined herein, tautomers thereof, stereoisomers thereof, including their mixtures, and salts thereof, and in particular physiologically tolerated salts thereof with inorganic or organic acids or bases. These compounds have valuable pharmacological properties, such as aggregation-inhibiting activity. This invention also relates to medicaments comprising these compounds and to processes for the preparation of these compounds.

Piperazine derivatives, medicaments comprising these compounds, their

The invention relates to cyclic urea derivatives of general formula I ##STR1## wherein R.sub.a, R.sub.b, X and Y are defined as in claim 1, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, preferably aggregation inhibiting effects, and to drugs containing the compounds and processes for preparing them.

Cyclic urea derivatives, pharmaceutical compositions containing these

The invention relates to cyclic derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined in claim 1, the tautomers, the stereoisomers including the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable pharmacological properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing the compounds and processes for preparing them.

Cyclic dericatives, pharmaceutical compositions containing these

5-Membered heterocyclic compounds, of which the following compounds are exemplary:

5-membered heterocycles, medicaments containing these compounds, their

Piperazine derivatives useful in the treatment or prevention of inflammation, bone degradation, thrombosis and tumor metastasis. Exemplary species are:

Piperazine derivatives, pharmaceutical compositions containing these

Cyclic compounds and pharmaceutical compositions containing them

The invention relates to bicyclic heterocyclic compounds of general formula ##STR1## wherein A to F, Y.sub.1 and Y.sub.2 are defined as in claim 1, the tautomers thereof, the stereoisomers thereof including their mixtures, and salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable pharmacological properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing the compounds and processes for preparing them as well as new intermediate products of general formula Ia.

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Warthausen, Germany

Brian Guth