Seres Therapeutics, Inc.

Children's Medical Center Corporation

Seres Health, Inc.

Ganna Bio, Inc.

Brian Goodman

Geoffrey Von Maltzahn

David Arthur Berry

David N Cook

Matthew R Henn

Marin Vulic

John Grant Aunins

Gregory McKenzie

Jonathan Winkler

Mary-Jane Lombardo Mckenzie

Mary-Jane Lombardo McKenzie

Noubar Boghos Afeyan

Carolyn Ruth Bertozzi

Richard D Cummings

Han Zhang

Namita Bisaria

Ryan A Flynn

Mohui Wei

Ciaran Lawlor

The present disclosure relates to glycan-modified nucleic acids, including short interfering RNA molecules. The glycan-modified nucleic acids include an oligosaccharide moiety that is bond to the nucleic acid and that contains a multiple antennary complex type N-glycan. The disclosure also relates to pharmaceutical compositions containing such glycan-modified nucleic acids, and methods for making and using such glycan-modified nucleic acids.

Glycan modified short interfering RNA

Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.

Methods for treatment of Clostridium difficile infection or recurrence or symptoms thereof

Compositions and methods

Methods and compositions for populating the gastrointestinal tract of a subject are described. Methods include administering to a subject a therapeutic composition comprising a purified population of spore-forming bacteria produced by providing a fecal material and subjecting the material to a treatment step resulting in purification of spore-forming bacteria. Methods include administering an amount effective to engraft and/or augment in the gastrointestinal tract in order to treat or prevent a dysbiosis in the mammalian subject.

Methods of populating a gastrointestinal tract

Provided are compositions containing combinations of bacteria useful for the maintenance or restoration of a healthy microbiota in the gastrointestinal tract, or other niche of a mammalian subject, and methods for use thereof, in particular for the treatment, inhibition, or prevention of immune disorders such as allergies and asthma.

Bacterial compositions and methods of use thereof for treatment of immune system disorders

Growing community of inventors

Boston, MA, United States of America

Brian Goodman