Zeneca Limited

Imperial Chemical Industries Limited

Brian Geoffrey Cox

John David Jones

Thomas Gray

Jan Michael Fielden

Gareth Andrew DeBoos

Paul Wilkinson

Stephen Martin Brown

Raymond Vincent Jones

Alan John Whitton

Daniel Levin

Michael S Howarth

Ian George Fleming

Gareth Andrew De Boos

Ian Gordon Berry

Process for the preparation of pyrimidine compounds

Process for making benzisothiazolin-3-ones

Manufacture of glyphosate salts

A process for the preparing agrochemical intermediates of formula (I): ##STR1## wherein W is (CH.sub.3 O) CH.CHCO.sub.2 CH.sub.3 or CH.sub.3 O.CH.dbd.CCO.sub.2 CH.sub.3 ; Z.sup.1 is a halogen atom; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, acetoxy or acyl; the process comprising the steps of:

Chemical process

Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, acetoxy or acyl, and processes for preparing the same.

Process for the preparation of

A method for the preparation of a 2-hydroxyarylaldehyde which comprises reacting an aryloxymagnesium halide derived from a phenol having at least one free ortho position relative to the phenolic hydroxy group with formaldehyde or a formaldehyde-liberating compound under substantially anhydrous conditions in the presence of a polar organic solvent other than hexamethylphosphoramide or 1,3-dimethyl-3,4,5,6-2(1H)-pyrimidone.

Chemical process for the preparation of a 2-hydroxyarylaldehyde

A method for the preparation of a pyridazinone derivative having the general formula I: ##STR1## where: R.sup.1 is a phenyl group, optionally substituted, R.sup.2 is H, alkyl or carboxy, R.sup.3 is H, alkyl or alkoxy and R.sup.4 is alkyl; said method comprising reacting a hydrazone of glyoxylic acid halide having the formula VII: ##STR2## in which X is halogen, with an ester of formula VIII; ##STR3## in the presence of an alkaline earth base.

Method of preparing pyridazinone derivatives

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Poynton, United Kingdom

Brian Geoffrey Cox