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21st Century Medicine Inc.

Brian G Wowk

Michael G Federowicz

Sandra R Russell

A method of cooling and rewarming large organs and tissues at sub-zero temperatures is provided. The method includes perfusion of tissue with inert fluids that remain liquid at very low temperatures. The inert fluids can include fluorocarbons, silicones, or fluorosilicones. Glycol ethers are used as a novel class of cryoprotective agents for organ and tissue preservation. The glycol ethers have improved viscosity, penetration, and glass forming properties.

Method for rapid cooling and warming of biological materials

A method of cryopreserving biological material by administering a cryoprotective agent mixture is provided. The mixture must be produced in a concentration sufficient to permit vitrification. The cryoprotective agent is an alkoxylated organic compound. The method includes administering the cryoprotective agent mixture and cooling the biological material until it is vitrified. Preferred cryoprotective mixtures contain 3 methoxy-1,2 propanediol and 2-methoxy ethanol.

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CA

Brian G Wowk