Glaxo Group Limited

Glaxo Laboratories Limited

Smithkline Beecham Corporation

Glaxco Group Limited

Brian Edgar Looker

Diane Mary Coe

Panayiotis Alexandrou Procopiou

Philip Charles Box

Keith Biggadike

Stephen Barry Guntrip

Alison Judith Redgrave

Christopher James Lunniss

Inderjit Singh Mann

Derek H Barton

Rajnikant Patel

Dean David Edney

Rebecca Jane Moore

Michael John Monteith

Abigail Halton

Alan Gibson Long

Edward McKenzie Wilson

Duncan Stuart Holmes

William George Underwood

Istvan Kaldor

Michael W Foxton

Paul Martin Gore

Sadie Vile

Richard Bell

Peter George Sammes

Derek Peter Reynolds

Alan Michael Chapman

Rita Field

Graham Hewitt

William G Elphinstone

Michael Joachim Kranz

The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases

Phenethanolamine derivatives for treatment of respiratory diseases

(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol and (5R)-3-(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one are claimed.

Compounds of the formula (II) and (IV) are provided, which may be employed as intermediates for making compounds useful in treating respiratory diseases.

The invention provides inhalation devices comprising a compound which is 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; or a salt or solvate thereof, inhalation devices comprising formulations and combinations of the compound or a salt or solvate thereof, and methods for the treatment or prophylaxis of a clinical condition in a mammal by employing the inhalation devices.

Inhalation devices for delivering phenethanolamine derivatives for the treatment of respiratory diseases

A compound of formula (I) or a salt, solvate, or physiologically functional derivative thereof, wherein: m is an integer of from 2 to 8; n is an integer of from 2 to 5; with the proviso that m+n is 4 to 10; Rand Rare independently selected from hydrogen and Calkyl with the proviso that the total number of carbon atoms in Rand Rnot more than 4; Rand Rare independently selected from hydrogen and Calkyl with the proviso that the total number of carbon atoms in Rand Ris not more than 4, and Aris a group selected from (a), (b), (c) and (d). 

Medicinal compounds

The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

Methods using phenethanolamine derivatives for treatment of respiratory diseases

The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

Phenethanolamine derivative for the treatment of respiratory diseases

The invention relates to 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; and salts and solvates thereof, including those which are pharmaceutically acceptable, along with formulations thereof, combinations thereof, and methods for the treatment or prophylaxis of mammals by administering such compounds.

The present invention relates to compounds of formula (I) as defined herein and salts or solvates thereof. Processes for preparing these compounds and pharmaceutical formulations containing them are also disclosed, as well as methods for the prophylaxis of treatment of a clinical condition using such compounds.

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The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases 

Compounds of formula (I): and uses of such compounds are described.

Compounds for use as surfactants

Compounds of formula (I): or salts or solvate thereof, wherein:

The present invention relates to novel compounds of formula (I), or a salt, solvate, or physiologically functional derivative thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

Growing community of inventors

Stevenage, United Kingdom

Brian Edgar Looker