Atherogenics, Inc.

Brian E Wadzinski

Russell M Medford

R Daniel Beauchamp

Rebecca Chinery

Robert J Coffey

A method to enhance the cytotoxic activity of an antineoplastic drug comprising administering an effective amount of the antineoplastic drug to a host exhibiting abnormal cell proliferation in combination with an effective cytotoxicity-increasing amount of an antioxidant. The invention also includes a method to decrease the toxicity to an antineoplastic agent or increase the therapeutic index of an antineoplastic agent administered for the treatment of a solid growth of abnormally proliferating cells, comprising administering an antioxidant prior to, with, or following the antineoplastic treatment.

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Nashville, TN, United States of America

Brian E Wadzinski