University of Michigan

Neoplasia Press, Inc.

Brian Dale Ross

Alnawaz Rehemtulla

Thomas L Chenevert

Craig Galban

Charles Raymond Meyer

Marcian E Van Dort

Charles R Meyer

Benjamin A Hoff

Kuei C Lee

Maha Hussein

Anne Schott

Lauren Daniel Stegman

Christopher Whitehead

Kenneth J Pienta

Nicholas S Burris

Peter B Kingsley

Kenneth Piente

Benjamin Lemasson

Dariya I Malyarenko

Ella Kazerooni

Craig J Galban

Kenneth Pienta

Thomas Chenevert

Maha Hussain

A voxel-based technique is provided for performing quantitative imaging and analysis of tissue image data. Serial image data is collected for tissue of interest at different states of the issue. The collected image data may be deformably registered, after which the registered image data is analyzed on a voxel-by-voxel basis, thereby retaining spatial information for the analysis. Various thresholds are applied to the registered tissue data to identify a tissue condition or state, such as classifying chronic obstructive pulmonary disease by disease phenotype in lung tissue, for example.

Tissue phasic classification mapping system and method

Inhibitors of mTOR, MEK, JAK and PI3K and compositions containing the same are disclosed. Methods of using the inhibitors in the treatment of a variety of diseases and conditions wherein inhibition of one or more of mTOR, MEK, JAK and PI3K provides a benefit also are disclosed. Methods of using chemical attachment moieties and linkers for the purposes of modifying compound solubility and/or lymphatic absorption are also disclosed.

Inhibitors of MEK/PI3K, JAK/MEK, JAK/PI3K/mTOR and MEK/PI3K/mTOR biological pathways and methods for improving lymphatic uptake, bioavailability, and solubility of therapeutic compounds

Multifunctional inhibitors of mTOR, MEK, and PI3K and compositions containing the same are disclosed. Methods of using the multifunctional inhibitors in the treatment of diseases and conditions wherein inhibition of one or more of mTOR, MEK, and PI3K provides a benefit, like cancers, also are disclosed.

Multifunctional inhibitors of MEK/PI3K and mTOR/MEK/PI3K biological pathways and therapeutic methods using the same

Thoracic aortic aneurysm is a common and lethal disease that requires regular imaging surveillance to determine timing of surgical repair and prevent major complications such as rupture. Current cross-sectional imaging surveillance techniques, largely based on computed tomography angiography (CTA) or magnetic resonance angiography (MRA), are focused on measurement of maximal aortic diameter, although this approach is limited to fixed anatomic positions and is prone to significant measurement error. The present techniques demonstrate novel approaches (generally termed herein 'Vascular Deformation Mapping (VDM)') for assessing changes in aortic dimensions. The present techniques quantify three-dimensional changes in the anatomic dimensions of a vessel through a process that involves non-rigid co-registration of serial imaging data and quantification of vascular deformation on a 3D surface model using some derivation of the spatial deformations resulting from the optimized spatial transform.

Techniques of deformation analysis for quantification of vascular enlargement

Computer-implemented methods are used to analyze a medical image to assess the state of the sample region. In at least one embodiment, the method comprises receiving at least one medical image collected previously from an image source, the at least one medical image comprising a plurality of voxels, each characterized by a signal value; classifying the signal value of each voxel as representing one of healthy tissue or diseased tissue based on a threshold value; and analyzing at least one topographical feature of the at least one medical image.

Systems and methods for topographical characterization of medical image data

Techniques for correcting gradient non-linearity bias in mean diffusivity measurements by MRI systems are shown and include minimal number of spatial correction terms to achieve sufficient error control using three orthogonal diffusion weighted imaging (DWI) gradients. The correction is based on rotation of system gradient nonlinearity tensor into a DWI gradient frame where spatial bias of b-matrix is described by its Euclidian norm. The techniques obviate time consuming multi-direction acquisition and noise-sensitive mathematical diagonalization of a full diffusion tensor for medium of arbitrary anisotropy.

Error analysis and correction of MRI ADC measurements for gradient nonlinearity

Dual inhibitors of MEK and PI3K and compositions containing the same are disclosed. Methods of using the dual MEK/PI3K inhibitors in the treatment of diseases and conditions wherein inhibition of MEK and PI3K provides a benefit, like cancers, also are disclosed.

Dual MEK/PI3K inhibitors and therapeutic methods using the same

The present invention provides systems and methods for monitoring tissue regions. In particular, the present invention provides systems and methods for detecting changes in tissue regions over a period of time. In some embodiments, the systems and methods of the present invention are used to evaluate the effectiveness of a particular treatment of a tissue region. In some embodiments, the systems and methods of the present invention provide a parametric response map approach for detecting and analyzing changes in tissue regions over a period of time to detect and monitor disease or tissue health and to monitor the impact of therapeutic interventions.

Systems and methods for imaging changes in tissue

A voxel-based technique is provided for performing quantitative imaging and analysis of tissue image data. Serial image data is collected for tissue of interest at different states of the issue. The collected image data may be normalized, after which the registered image data is analyzed on a voxel-by-voxel basis, thereby retaining spatial information for the analysis. Various thresholds are applied to the registered tissue data to predict or determine the evolution of a disease state, such as brain cancer, for example.

Voxel-based approach for disease detection and evolution

The present invention provides systems and methods for monitoring tissue regions. In particular, the present invention provides systems and methods for detecting changes in tissue regions over a period of time. In some embodiments, the systems and methods of the present invention are used to evaluate the effectiveness of a particular treatment of a tissue region. In some embodiments, the systems and methods employ functional diffusion map algorithms for imaging changes in tissue regions over time and/or in response to therapeutic interventions.

Systems and methods for tissue imaging

An improved method for facilitating the peer review process in scholarly publications is presented. This improved method streamlines and compresses the review process, eliminating unnecessary delays and costs inherent in the traditional process. The present invention implements a computer based manuscript tracking process the uses the World Wide Web to allow ubiquitous access to the manuscript under review. This ubiquitous access works in conjunction with automatic generation of potential reviewers and instant notification to authors, editors, and reviewers of significant milestones in the peer review process. Authors are allowed to communicate with anonymous reviewers to reduce the number of revisions leading to approval. Additionally, multiple authors are allowed to collaborate during the manuscript creation process as well as the manuscript review process. This allows several geographically disperse authors to conveniently co-author a manuscript. It additionally allows the author or several authors to respond to comments from the reviewer prior to an editor reading the review.

System and method for facilitating the pre-publication peer review process

The invention provides compositions and methods for non-invasive imaging of enzyme (e.g., protease) activity in cells, tissues and organs and entire bodies in vitro, in vivo and in situ. The invention provides a chimeric polypeptide having a bioluminescent or chemiluminescent polypeptide, or a heterologous kinase, and at least one silencing moiety, and a protease cleavage motif positioned between the first and second domains. The imaging can be by computer assisted tomography (CAT), magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), or bioluminescence imaging (BLI).

Growing community of inventors

Ann Arbor, MI, United States of America

Brian Dale Ross