Beckman Coulter, Inc.

Brian D Wilson

Alan N Johnson

Joshua D Wiltsie

Matthew S Davis

Humayun Qureshi

Garrick A Maurer

Daniel R Schmidt

Matthew D Erickson

Peter G Werness

Robert J Mattila

Mark J Kittock

Mark F Sauerburger

David L Anderson

Michael J Rosen

Ronald C Laska

Armer J Willenbring

Robert A Weiss

Dang Minh Ngo

Glenn A Davis

David Lin Yang

Charles S Kraihanzel

Sami D Alaruri

Thomas M Stachelek

Donald J Gjerdingen

Bernhard Spiess

Bernhard Spless

Bernard Spiess

Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.

Reagent cartridge

A method and system of sample aliquot storage for automated immunochemistry or chemistry instruments are provided. The method and system provide a sample aliquot storage unit having a sample storage wheel for storing sample vessels containing sample aliquots in a chilled enclosed environment, which are accessible by both a sample pipettor of a sample aliquoting station and a pick-and-place gripper. The pick-and-place gripper transports the sample vessels containing sample aliquots to multiple independent reagent pipetting stations respectively for sample aspiration of subsequent assay, and thereafter transports the sample vessels containing remaining sample aliquots back to the sample storage wheel to be stored in the chilled environment for reflex testing. When all the tests are completed, the pick-and-place gripper transports the sample vessels to a waste storage area.

Method and system for sample aliquot storage

Reaction vessel

Assay cartridge with reaction well

System and method for controlling thermal cycler modules

System and method including multiple processing lanes executing processing protocols

System and method including thermal cycler modules

System and method including analytical units

An assembly suitable for use in a laboratory instrument is set forth. The assembly comprises a plurality of guide rods that are disposed generally parallel with one another and a plurality of carriage assemblies connected for movement along the plurality of guide rods. A sub-carriage assembly is disposed on at least one of the carriage assemblies and is connected to the carriage assembly for movement in a direction transverse to the plurality of guide rods. A plurality of carriage drive mechanisms are employed to move the plurality of carriage assemblies independently along said plurality of guide rods and a sub-carriage drive mechanism is provided to move the sub-carriage assembly in a direction transverse to said plurality of guide rods.

Apparatus having improved gantry assembly suitable for use in a laboratory environment

An automated analyzer is configured to receive and analyze samples provided to the automated analyzer in primary sample containers. The automated analyzer comprises a sample retention unit, at least one transport device, and at least one aspiration device. The sample retention unit is configured to receive and retain a plurality of sample retention vessels. The sample retention unit may comprise a sample storage unit, an analytic unit, or other processing unit within the automated analyzer that retains a sample for some purpose. The transport device is configured to receive a first primary sample container containing a first sample and deliver the first primary sample container to the sample retention unit as one of the plurality of sample retention vessels. The aspiration device is configured to receive a second sample from a second primary sample container and deliver the second sample into one of the plurality of sample retention vessels.

Method and device for test sample loading

A rotary incubation station for an automated analyzer is provided. The rotary incubation station includes a platform, a circular ring-shaped outside rotary wheel having a plurality of nesting locations for washing and reading vessels, and a circular disc-shaped inside rotary wheel having a plurality of nesting locations for incubation and storage of vessels. The rotary incubation station also includes a spur gear mechanism for rotating the outside and inside rotary wheels, including spur gear drivers respectively engaged with spur gear teeth of the outside and inside rotary wheel, providing accurate control of the rotation of the outside and inside rotary wheels.

Rotary incubation station for immunoassay systems

A method and system for picking and placing vessels are provided. The system includes a gripper assembly mounted on a positioning mechanism. The gripper assembly includes a cylinder, a plurality of flexible gripping members extending from the cylinder in a spaced-apart relationship for receiving therebetween a vessel and holding it by friction, a piston slideably inserted inside the cylinder, and a plunger connected to and movable with the piston and extending between the gripping members for engaging the vessel. The method includes the steps of positioning the gripper assembly, picking up and transferring a vessel, and placing, seating and releasing the vessel. The contents of the vessel may also be mixed simultaneously during the transferring of the vessel.

Method and system for picking and placing vessels

A method and system for automated immunochemistry or chemistry analysis are provided. The method and system provide a sample aliquoting section, a reagent pipetting section having a plurality of independent reagent pipetting stations, each operating on a cycle of a first period of time, and an incubate and wash and read section operating on a cycle of a second period of time to match the throughput of the system, where the quotient of the first period of time divided by the second period of time is a whole number, and the number of the independent reagent pipetting stations being equal to the whole number. The respective cycles of the independent reagent pipetting stations are staggered apart by the second time period, such that at least one of the multiple independent pipetting stations is available for working with the incubate and wash and read section at each operating cycle of the second period of time.

Method and system for automated immunochemistry analysis

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Chaska, MN, United States of America

Brian D Wilson