The University of Texas System

Dow Global Technolgoies LLC

Hoechst Marion Roussel

Aventis Pharmaceuticals Inc.

Aventisub II Inc.

Brian D Scherzer

James E Hitt

Keith P Johnston

Robert O Williams, Iii

Christopher John Tucker

Timothy J Young

True L Rogers

Douglas C Greminger

Jason T McConville

Robert Talbert

Jay I Peters

David A Hayes

David S Burgess

Mark R Smit

Ian B Gillespie

Paula C Garcia

Nicholas S Beck

Mark A Nitz

Sandra Stolz-Dunn

Christian T Goralski

Jonathan C Evans

Ronald B Leng

Avani Maulik Patel

David H Louks

Sandra K Stolz-Dunn

Derrick G Wetters

Douglas Carl Greminger

Inhalable compositions are described. The inhalable compositions comprise one or more respirable aggregates, the respirable aggregates comprising one or more poorly water soluble active agents, wherein at least one of the active agents reaches a maximum lung concentration (C) of at least about 0.25 &#x3bc;g/gram of lung tissue and remains at such concentration for a period of at least one hour after being delivered to the lung. Methods for making such compositions and methods for using such compositions are also disclosed.

Enhanced delivery of drug compositions to treat life threatening infections

The present invention is a method for preparing micron-sized or submicron-sized drug particles comprising contacting a solution comprising a poorly water soluble drug substance and at least one freezable organic solvent with a cold surface so as to freeze the solution; and removing the organic solvent. The resulting particles are also disclosed, as are several embodiments of an apparatus that can be used in performing the method of the present invention.

Drug particles from freezing onto a surface

Brominated butadiene polymers are recovered from solution and formed into particles by spraying the solution onto a heated, mechanically agitated bed of seed particles. The droplets contact the seed particles in the bed and form a polymer layer on the outside of the seed particles, thereby enlarging them. The solvent is removed from the droplets after they make contact with seed particles in the bed. The process allows for the simultaneous removal of solvent and formation of somewhat large particles. The process forms at most small amounts of agglomerates and fines.

Process for forming and devolatilizing brominated polybutadiene polymer particles

Brominated polybutadiene polymers are recovered from a bromination reaction solution by forming the solution into droplets, thermally stripping the solvent from the droplets, and then washing the resulting particles. The washed particles are then recovered from the washing liquid. The droplets can be dispersed into a gaseous medium such as air and then transferred into a nonsolvent liquid for washing, or can be formed directly into the nonsolvent liquid. The process forms a particulate polymer material that is easily filterable and has low levels of volatile impurities and inorganic salts. Brominated polybutadiene polymers recovered in this manner are often very thermally stable.

Process for recovering brominated butadiene polymers from solution

The present invention relates to a process for preparing a compound of formula (I): ##STR1## wherein R is C.sub.1 -C.sub.10 alkyl, phenyl or substituted phenyl, comprising treating a compound of formula (II): ##STR2## with bis(tributyltin) oxide in an organic solvent selected from the group consisting of o-xylene, m-xylene, p-xylene and mixed xylenes; and subsequently treating the reaction mixture with a compound of formula (III): ##STR3## wherein X is halogen and R is defined as above.

Process for preparing 6-0-monoesters of castanospermine

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Midland, MI, United States of America

Brian D Scherzer