Massachusetts Institute of Technology

Nucleus Scientific Inc.

Other

Brian D Hemond

Ian W Hunter

Andrew James Taberner

Dawn M Wendell

Nathan Barker Ball

Harold F Hemond

Nora Catherine Hogan

Serge R Lafontaine

Nickolas P Demas

N Catherine Hogan

Grant W Kristofek

Adam Wahab

Michael Thomas Nawrot

Nathan B Ball

Catherine N Hogan

Andrew J Taberner

A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.

Methods, apparatus, and system for mass spectrometry

A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

Controlled needle-free transport

An energy storage system for use with an external device including: an energy storage cell; a microcontroller; an internal communication bus; an interface including two power terminals and a communications port electrically connected to the internal communication bus; power conversion circuitry for performing a charging operation during which energy is transferred from the power terminals to the energy storage cell and a discharging operation during which energy is transferred from the energy storage cell to the power terminals; and one or more sensors for monitoring one or more parameters of the energy storage cell, wherein it is all packaged to form a single, integrated unit.

Instrumented super-cell

A battery assembly including: a plurality of prismatic battery cells; first and second fluid manifolds; and a plurality of corrugated flow plates interleaved with the plurality of battery cells, each the flow plates extending from the first manifold to the second manifold and providing an array of flow channels for carrying fluid from the first manifold to the second manifold, wherein each plate of the plurality of corrugated flow plates is an extruded plastic structure comprising first and second fluid impermeable sheets and a plurality of parallel ribs between and connecting the first and second sheets, said plurality of ribs forming the array of flow channels.

Multi-cell battery assembly

A device for the measurement of forces on the tip of a jet injector drug ampoule. Sensor consists of multiple spokes with strain sensing capability where each spoke has a modified linkage to allow for quasi-free bending behavior on one spoke end. By using the strain output of all three full bridges in parallel, it is possible to discriminate between lateral forces and axial forces directed collinear with the center axis of the ampoule applied to the tip of the nozzle. This information can be relayed to the user to attain, for example, a pre-determined contact force between the nozzle and an area receiving an injection.

Multi-directional low-displacement force sensor

A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.

Injection methods using a servo-controlled needle-free injector

A needle-free transdermal transport device includes a chamber () for holding the substance to be injected, a nozzle () in fluid communication with the chamber, and a drug reservoir () for storing the substance to be transferred to the chamber. The needle-free transdermal transport device also includes a controllable magnet and coil electromagnetic actuator () in communication with the chamber. The actuator receives an electrical input and generates in response a force. The force then causes a needle-free transfer of the substance from the chamber to the biological body. The force is variable responsive to variations in the received input during actuation. The actuator draws the substance from the drug reservoir or alternatively, the substance can be pressurized from the drug reservoir into the chamber by a pressure source.

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Cambridge, MA, United States of America

Brian D Hemond