Mallinckrodt, Inc.

Brian D Doty

Muthunadar P Periasamy

Michael Scott Hughes

William A Hagen

Gordon Persaud

The present invention generally relates to nonionic x-ray contrast media formulations, radiological compositions containing such agents and methods for x-ray visualization utilizing such compositions. The invention especially relates to injectable radiological compositions for x-ray visualization comprising a pharmaceutically acceptable vehicle and a mixture of a monomer, being a triiodo-substituted benzene nucleus, and a dimer, being two linked triiodo-substituted benzene nuclei, such that the mixture demonstrates favorable properties.

Low osmolar X-ray contrast media formulations

A device and method for providing a suspended agent such as a contrast agent without mechanical resuspension. A volume of agent ( ) is divided into sub-volumes in a network ( ) of tubes ( ), cells ( ), sponges ( ), grooves ( ), etc. A propellant fluid ( ) flows through the network ( ) to release the suspended agent ( ). The network ( ) may be internal to a container ( ) for the propellant fluid ( ). Alternatively, the network ( ) may be adjacent an exit port ( ) of a container ( ) for the propellant fluid ( ), or may be in-line between a propellant fluid container ( ) and a patient. The invention reduces sedimentation of agents into one or a few aggregates and eliminates a mechanical mixing step. The invention thus provides a uniformly suspended agent, improving patient health and safety and increasing cost and time savings.

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St. Peters, MO, United States of America

Brian D Doty