Novartis Ag

Other

Brian Cox

Simon James Watson

David Andrew Sandham

Kamlesh Jagdis Bala

Katharine Louise Turner

Lyndon Nigel Brown

Urs Baettig

Catherine LeBlanc

Stephen Paul Collingwood

Ian Bruce

Robin Alec Fairhurst

Catherine Leblanc

Roger John Taylor

Neil John Press

Judy Fox Hayler

Sudhakar Devidasrao Garad

Dimitris Papoutsakis

Hyungchul Kim

Suzanne Elaine Keeling

Catherine Howsham

Lee Edwards

Emma Budd

Gurdip Bhalay

Michael David Barker

Graham Charles Bloomfield

David George Allen

Darren Mark Legrand

Nicholas James Devereux

Jake Axford

Heather Hobbs

Alison Judith Redgrave

Thomas Davis Roper, Iv

Joanna Victoria Geden

There are provided according to the invention compounds of formula (I) in free or salt form, wherein R, R, R, R, R, R, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.

Pyrrolopyridine derivatives and their use as CRTH2 antagonists

The present invention concerns a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, where R-Rand Y are defined in the description, and its use in the treatment of disorders in which pi3 kinase is implicated.

Pyrazolo [3,4-D] pyrimidine derivatives useful to treat respiratory disorders

There are provided according to the invention compounds of formula (I), in free or salt form, wherein R, R, R, R, R, R, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals. 

Organic compounds

A compound of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof, and their preparation and use as pharmaceuticals 

Compounds of formula I in salt or zwitterionic form wherein, wherein R, R, R, and Rhave the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

Quinuclidine derivatives binding to mucarinic M3 receptors

Compounds of Formula (I); in salt or zwitterionic form wherein R, R, Rand Rhave the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described. 

Quinuclidine derivatives and their use as muscarinic M3 receptor antagonists

The present invention concerns a compound of formula Ia wherein: Ris hydrogen or C-C-alkyl; Ris &#x2014;(C-C-alkylene)-Y&#x2014;C-C-haloalkyl or &#x2014;(C-C-alkylene)-Y&#x2014;C-C-hydroxyalkyl; Y represents &#x2014;CONH&#x2014; or a five membered heteroaryl group. Ris C-C-alkyl or halogen; Ris halo, &#x2014;SO&#x2014;CH, &#x2014;SO&#x2014;CF, carboxy, &#x2014;CO&#x2014;NH, &#x2014;CO-di(C-C-alkyl)amino, or a 5- or 6-membered heterocyclic ring having one or more ring hetero atoms selected from the group consisting of oxygen, nitrogen and sulphur, that ring being optionally substituted by halo, cyano, oxo, hydroxy, carboxy, nitro, C-C-cycloalkyl, C-C-alkylcarbonyl, C-C-alkoxy optionally substituted by aminocarbonyl, or C-C-alkyl optionally substituted by hydroxy, C-C-alkoxy, C-C-alkylamino or di(C-C-alkyl)amino; Ris hydrogen, halo, &#x2014;SO&#x2014;CH, nitrile, C-C-haloalkyl, imidazolyl, C-C-alkyl, &#x2014;NRR, or &#x2014;SO&#x2014;NRR; and Ris hydrogen, halogen or C-C-alkyl; Rand Rare independently hydrogen, amino, C-C-alkylamino, di(C-C-alkyl)amino, or CC-C-alkyl optionally substituted by hydroxyl; or a pharmaceutically acceptable salt, or solvate thereof, to compositions and use of the compounds in the treatment of diseases ameliorated by inhibition of phosphatidylinositol 3-kinase. 

5-phenyl-thiazol-2-yl-urea derivatives and use as PI3 kinase inhibitors

Quinuclidine derivatives and their use as muscarinic m3 receptor antagonists

Compounds of formula (I) in free or pharmaceutically acceptable salt form, where R, R, R, R, R, R, R, m, n, w, X, and Y have the meanings as indicated in the specification, are useful for treating conditions mediated by the CRThreceptor, especially inflammatory or obstructive airways diseases.

Organic compounds for the treatment of inflammatory or allergic conditions

There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R 4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.

Pyrrolopyridine derivatives and their use as Crth2 antagonists

2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives

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Horsham, United Kingdom

Brian Cox