Vanderbilt University

University of Florida Research Foundation, Incorporated

The United States Government As Represented by the Department of Veterans Affairs

Brian Connor Evans

Craig L Duvall

Colleen M Brophy

Benjamin George Keselowsky

Kyle Hocking

Jamal Lewis

Lawrence Premasiri Fernando

Lirong Yang

The present disclosure relates to compounds comprising (i) an active agent, wherein the active agent includes a charge at a predetermined pH, (ii) a polymer, wherein the polymer includes an opposite charge than the active agent at the predetermined pH; and (iii) a polyplex comprising the peptide and the polymer electrostatically bond together at the predetermined pH. In some embodiments, the active agent is a peptide, such as a peptide comprising MAPKAP kinase II inhibitory peptide, and in some embodiments the peptide includes a cell-penetrating peptide. In further embodiments, the disclosure provides methods for treating a disease or condition by administering a composition according to the present disclosure to a subject in need thereof.

Polyplexes

Embodiments of the present disclosure include particles, methods of making particles, methods of delivering an active agent using the particle, and the like.

Polymeric particles, method for cytosolic delivery of cargo, methods of making the particles

Growing community of inventors

Bartlett, TN, United States of America

Brian Connor Evans