The United States of America, As Represented by the Secretary, Department of Health and Human Services

The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth, Near Dublin

Brian Christopher O'Connell

Bruce J Baum

Changyu Zheng

Paul Phillips

Ramesh Babu Padamati

James Joseph Doyle

Dermot Joseph Sullivan

Padraig Martin McAuliffe

Padraig Martin Mcauliffe

The invention provides a sensor assembly embeddable within an oral appliance comprising a sensing means; and a data processing means coupled to the sensing means for processing data obtained by the sensing means; wherein the sensing means and the data processing means are sealed within a deformable layer.

Sensor for an oral appliance

An adenovirus, including adenoviral capsid proteins, and a replication-defective adenoviral vector that includes a 5' retroviral LTR nucleic acid sequence, a 3&#x2032; retroviral LTR nucleic acid sequence, a nucleic acid sequence encoding a portion of a retroviral envelope protein adjacent to either the 5&#x2032; LTR or the 3&#x2032; LTR nucleic acid sequence, a retroviral packaging sequence and a nucleic acid sequence encoding a transgene located between the 5&#x2032; LTR and the 3&#x2032; LTR is provided. Host cells infected with this adenovirus are also provided. An adenoviral vector is provided that includes an adenoviral polynucleotide sequence comprising a nucleic acid encoding a transgene, a retroviral packaging signal, a 5&#x2032; and a 3&#x2032; retroviral LTR, and a portion of a retroviral envelope polypeptide, wherein the adenoviral polynucleotide sequence does not encode one or more of E1, E3 or E4. A method for transforming a cell is also provided using a virus or a vector of the invention, as is a method for introducing a transgene into a cell that is not able to produce viral particles with a single viral vector. A method is also provided for preventing or treating disorder in a subject using the adenoviral vectors of the invention. A pharmaceutical composition is also provided that includes an adenoviral vector of the invention and a pharmaceutically acceptable carrier.

Hybrid adeno-retroviral vector for the transfection of cells

An adenoviral vector is disclosed that includes two adenoviral ITRs, wherein the two adenoviral ITRs flank a packaging signal and a single retroviral LTR operably linked to a nucleic acid sequence of interest, wherein the adenoviral vector does not include a nucleic acid sequence encoding the retroviral structural proteins and wherein the adenoviral vector does not include a second retroviral LTR. In one embodiment, a method for transforming a cell is disclosed. In another embodiment, a method is disclosed for introducing a transgene into a cell with a single viral vector. In a further embodiment, a method is provided for preventing or treating disorder in a subject. A pharmaceutical composition is also provided.

Hybrid adenoviral vector

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Dublin, Ireland

Brian Christopher O'Connell