Juno Therapeutics Gmbh

Brian Christin

Mark J Gilbert

He Li

Christopher Glen Ramsborg

Claire L Sutherland

Clinton Weber

Rachel K Yost

Tina Albertson

Jacob Randolph Garcia

Jeff D Smith

Pascal Beauchesne

Ryan P Larson

Tom Kowski

Calvin Chan

Nathan K Yee

Valerie Odegard

Kathryn Lindsay Pollock

Ruth Berry

Andrew W Walker

Kedar Himanshu Dave

Mary Mallaney

Janelle Stoops

Nikolaus Sebastian Trede

Michael Gerard Covington

Richard James Getto, Jr

James Boyd Whitmore

Travis Beckett

Samuel Charles Blackman

Nathaniel Chartrand

Nathaniel Lambert

Kien Khuu-Duong

Mel Davis-pickett

Kien Khuu-duong

Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions.

Determining toxicity risk in CAR T-cell therapy

Provided are adoptive cell therapy methods involving the administration of doses of cells for treating disease and conditions, including certain B cell malignancies. The cells generally express recombinant receptors such as chimeric antigen receptors (CARs). In some embodiments, the methods are for treating subjects with non-Hodgkin lymphoma (NHL). In some embodiments, the methods are for treating subjects with relapsed or refractory NHL. Also provided are articles of manufacture and prophylactic treatments in connection with adoptive therapy methods.

Articles of manufacture and methods for treatment using adoptive cell therapy

Provided herein are methods of assessing or determining the presence or absence of particles, such as bead particles, present in a cell composition. Also provided are articles of manufacture and kits for use in the methods.

Methods of enumerating particles present in a cell composition

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Seattle, WA, United States of America

Brian Christin