Amgen Inc.

Medarex Inc.

C3 Jian, Inc.

Other

E. R. Squibb Sons, Inc.

Brian C Varnum

Haichun Huang

Francis Hall Martin

Alison Witte

Gary Elliott

Randal H Eckert

Frank Martin

Xueming Qian

Chris Vezina

Evan Schauer

Miroslav Baudys

Christopher W Kaplan

Claudio Schneider

Giancarlo Avanzi

Guidalberto Manfioletti

Gary Elliot

Claudio Brancolini

Jay Turetzky

Angela Soriaga

Duane Morris

In certain embodiments a dental strip for the prevention or reduction of dental caries is provided. In certain embodiments the dental strip is constructed to deliver effective amounts of specifically targeted antimicrobial peptides (or simple antimicrobial peptides) and comprises an orally compatible backing layer, a delivery layer disposed on one surface of the backing layer where the delivery layer comprises an orally compatible polymer, or combination of polymers, and a specifically targeted antimicrobial peptide (and/or simple antimicrobial peptide) capable of binding and killing. In certain embodiments the dental strip additionally comprises a release liner.

Dental strips for the delivery of specifically targeted antimicrobial peptides

In various embodiments a dental varnish system having improved peptide release and fluoride release properties is provided. In various embodiments a dental varnish system that provides release of an antimicrobial peptide, or specifically targeted antimicrobial peptide (STAMP), e.g., the peptide C16G2, is provided, with or without a fluoride. In various embodiments, a dental varnish system that provides release of a fluoride, with or without an antimicrobial peptide or STAMP is provided. In certain embodiments the dental varnish system comprises a first component that is a dry powder, said first component comprising a an antimicrobial peptide, with or without a fluoride, and a bulking agent, and a second component that is a fluid, said second component comprising a varnish solution, where combination of said first component with said second component provides a varnish formulation for application to the surface of a tooth.

Dental varnishes that release specifically targeted antimicrobial peptides and/or fluoride

Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.

Therapeutic human anti-IL-1R1 monoclonal antibody

Therapeutic human anti-IL1-R1 monoclonal antibody

A protein which is a stimulator of and presumed ligand for the axl receptor has been identified and sequenced. The protein, termed gas6, bears homology to human protein S and is a growth factor for tissues which express axl.

DNA encoding a stimulating factor for the axl receptor

Growing community of inventors

Santa Monica, CA, United States of America

Brian C Varnum