University of Iowa Research Foundation

Brian C Schutte

David A Schwartz

Paul B McCray, Jr

Hong Peng Jia

Brian F Tack

Eva Lorenz

Fred S Lamb

Baoli Yang

The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.

Variant TLR4 nucleic acid and uses thereof

The present invention provides methods for the modulation of vascular tone in a patient having compromised vascular tissue, which methods comprise the administration of a chloride channel blocking agent or a pharmaceutically acceptable salt thereof.

Use of ClC3 chloride channel blockers to modulate vascular tone

The present invention relates a novel antimicrobial peptide HBD-3 and derivatives thereof as well as the gene encoding the peptide. The invention further relates to methods of use of the HBD-3 peptide including a method of inhibiting microbial growth by administering an effective amount of the HBD-3 peptide alone or in combinination with other antimicrobial agents or antibiotics. In addition, the immunomodulatory properties of the HBD-3 peptide also facilitate the manipulation of the immune response, i.e., as a chemoattractant for immature dentritic cells or memory T cells.

Human beta-defensin-3 (HBD-3), a highly cationic beta-defensin antimicrobial peptide

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Iowa City, IA, United States of America

Brian C Schutte