Edwards Lifesciences Corporation

Terumo Corporation

Endologix, Inc.

Valcare, Inc.

Micardia Corporation

Brian C Gray

Thanh Huy Le

Tung Thanh Le

Sonny Tran

Alejandro J Froimovich Rosenberg

Samuel M Shaolian

Robert R Bowes

Ross Tsukashima

Maurice Buchbinder

Uy D Trinh

Hamid Rafi

Maria Lillian Saravia

Andrew Oien

Kim D Nguyen

Hung H Cao

Kevin D Rupp

Victor S Packham

Jeff Lindstrom

Maricela D Walker

Anup Dasnurkar

Michael Martel

Jeffrey P Dumontelle

Trinh Van Pham

Myles S Douglas

Kevin Mayberry

Frida San

Shawn O'Leary

Daniel C Anderson

Frank M Zeng

Vincent Yeh

Frank Shannon

Paul A Molloy

Ninh H Dang

Kevin J Mayberry

Disclosed embodiments of introducer devices provide hemostatic sealing and allow a delivery catheter to be inserted through the introducer seals without the use of a separate loader device that covers a medical device that is mounted on the catheter. Some disclosed introducers comprise a housing, a distal sheath extending distally from the housing and adapted to be inserted into a patient's vasculature, a distal hemostatic seal mounted within the housing and a proximal hemostatic seal mounted within the housing, and a slidable tube positioned within the housing that is movable longitudinally relative to the distal hemostatic seal between a proximal position and a distal position, wherein in the proximal position a distal end of the tube is positioned proximal to the distal hemostatic seal with the distal hemostatic seal closed, and wherein in the distal position the distal end of the tube extends through the distal hemostatic seal.

Intravascular introducer devices

A delivery apparatus for implanting a radially compressible and expandable prosthetic heart valve in a native heart valve of the heart includes a handle portion and an elongated shaft extending from and movable relative to the handle portion. The shaft includes a proximal end portion coupled to the handle portion and a distal end portion configured to mount a prosthetic heart valve in a radially compressed state. The handle portion includes a control member movable longitudinally with respect to the handle portion, the control member engaging a gear assembly operable to convert longitudinal motion of the control member to rotational motion of the gear assembly. The gear assembly engages the elongated shaft such that rotational motion of the gear assembly causes corresponding longitudinal motion of the elongated shaft relative to the handle portion.

Delivery system for prosthetic heart valve

An occlusion device with particular utility in occlusion of left atrial appendages is described. The occlusion device embodiments utilize an inflatable balloon or expandable element used to occlude the treatment site.

Occlusion systems

System and methods of delivering adhesive material are described for occluding target locations within a patient. The systems include a catheter configured to deliver adhesive to a target location and one or more of a light source to harden the adhesive, a retention structure to contain the adhesive prior to curing, a balloon to occupy a target location, and an open cell foam plug to occupy a target location.

Adhesive occlusion systems

Apparatus, systems, and methods are provided for repairing heart valves through percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves. An annuloplasty ring includes an outer hollow member including a plurality of segments. Adjacent segments cooperate with one another to change the outer hollow member from an elongate insertion geometry to an annular operable geometry. The annuloplasty ring also includes an internal anchor member located at least partially within the outer hollow member. The internal anchor member includes a plurality of anchors configured to attach the annuloplasty ring to tissue of a heart valve annulus. The internal anchor member is configured to move the plurality of anchors with respect to a plurality of windows in the outer hollow member to selectively deploy the plurality of anchors through the respective windows.

Percutaneous transcatheter repair of heart valves

Annuloplasty rings are employed to treat heart valve defects, such as regurgitation. Synching the heart tissue to the ring restores the valve opening to its approximate original size and operating efficiency. Adjustable annuloplasty rings allow for a proper degree of synching both during open heart surgery and over the patient's lifetime. A subcutaneous port may be coupled to an adjustable annuloplasty ring such that an external activation energy generator can be used to heat the adjustable annuloplasty ring and thereby adjust the size of the annuloplasty ring.

Adjustable annuloplasty ring with subcutaneous activation port

Annuloplasty rings reduce or eliminate tricuspid regurgitation and/or tricuspid annulus dilation. An adjustable annuloplasty device includes a ring body having a first free end and a second free end. The ring body includes a shape memory material to provide a shape change to the adjustable annuloplasty device upon activation. The ring body includes a first segment including the first free end and following a curved path corresponding to an anterior leaflet region of a tricuspid annulus, a second segment following a curved path corresponding to a posterior leaflet region of the tricuspid annulus, and a third segment including the second free end and at least partially following a linear path corresponding to a portion of a septal leaflet region of the tricuspid annulus. Activation of the shape memory material changes a dimension of the adjustable annuloplasty device.

Adjustable tricuspid ring

A guidewire assembly for use in deploying a bifurcated endoluminal vascular prosthesis that has a main graft portion and at least a first branch graft portion The guidewire assembly include a hollow guidewire sheath having a restraint mechanism, such as a tubular sheath, for constraining a branch graft portion of the vascular prosthesis and an inner core wire that is slidably insertable into a central lumen of the hollow guidewire sheath. In use, the guidewire assembly may be used with a deployment catheter to deploy the bifurcated vascular prosthesis and leave the inner core wire in position in the patient's aorta, extending through the main graft portion of the vascular prosthesis.

Dual concentric guidewire and methods of bifurcated graft deployment

The present invention is related to a low profile endolumenal prosthesis. The prosthesis comprises a radially expandable tubular wire support and an expanded PTFE membrane. The density, wall thickness and intranodal distance of the ePTFE are selected to inhibit the formation and nourishment of a viable neointima on the inner surface of the prosthesis, through the ePTFE membrane.

Endolumenal vascular prosthesis with neointima inhibiting polymeric sleeve

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Lake Forest, CA, United States of America

Brian C Gray