Clearside Biomedical, Inc.

Brian Burke

Vladimir Zarnitsyn

Daniel White

Glenn Noronha

Samirkumar Rajnikant Patel

Samirkumar Patel

Cong Thanh Dinh

Mark R Drane

Rafael Victor Andino

Edward Lee

Jennifer Kissner

Thai Q Nguyen

Ian Rubin Borbolla

Andrew J Feudner

The present disclosure relates to pharmaceutical suspensions of triamcinolone acetonide, methods of producing such suspensions and methods of using of such suspensions. The pharmaceutical suspensions of the present disclosure are stable and suitable for administration by suprachoroidal injection through a 30-gauge microneedle.

Injectable triamcinolone formulations

Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

Methods and devices for the treatment of ocular diseases in human subjects

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Cary, NC, United States of America

Brian Burke