Zymogenetics, Inc.

Bristol-myers Squibb Compnay

Brian A Fox

Paul O Sheppard

Scott R Presnell

Wayne R Kindsvogel

Kevin M Klucher

David W Taft

Francis J Grant

Betty A Haldeman

Teresa Gilbert

Wenfeng Xu

Mark W Rixon

Margaret Dow Moore

Cameron Brandt

Carl W Birks

Donald C Foster

Cindy A Sprecher

James D Kelly

Karen L Madden

Zeren Gao

Jeff Lynn Ellsworth

James L Holloway

Eugene C Yi

Jacob J Kennedy

Pallavur V Sivakumar

Kristine M Swiderek

Christine C Anderson

Terence J Anderson

Mark Hoben

Stacey R Dillon

Robert R West

Sean Michael McCann

Cameron S Brandt

Disclosed are soluble hybrid Fc&#x3b3; receptor (Fc&#x3b3;R) polypeptide compositions and related methods of using such polypeptides to treat IgG-mediated and immune complex-mediated inflammation. Also disclosed are related compositions and methods for producing the soluble hybrid Fc&#x3b3;R polypeptides.

Soluble hybrid Fc&#x3b3; receptors and related methods

Disclosed is a newly identified B7 family member, zB7H6, which functions as a counter-receptor for the NK cell triggering receptor, NKp30. Methods and compositions for modulating NKp30-mediated NK cell activity based on the interaction of zB7H6 with NKp30, as well as related screening methods, are also disclosed. Further disclosed are anti-zB7H6 antibodies as well as antibody-drug conjugates comprising an anti-zB7H6 antibody conjugated to a therapeutic agent, including methods for using such antibodies and antibody-drug conjugates to exert therapeutic effects against zB7H6-expressing cells.

B7 family member zB7H6 and related compositions and methods

Cooler lid

The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-&#x3b1; at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.

Cytokine protein family

A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.

Methods of treating inflammatory disease using a soluble IL-20 receptor

Cytokine Protein Family

The present invention relates to a method of preparing a trimeric protein comprising culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a ZymoZipper (ZZ) domain and a heterologous protein. In one embodiment, the heterologous protein is a membrane protein, the portion of the heterologous protein that included in the fusion protein is the extracellular domain of that protein, and the resulting fusion protein is soluble. In another embodiment of the present invention, the ZZ domain is derived from the transmembrane (TM) subunit of a virus envelope protein or another heptad repeat containing gene of a virus genome. The method can be used to produced homo- and hetero-trimeric proteins. The present invention also encompasses DNA molecules, expression vectors, and host cells used in the present method and fusion proteins produced by the present method.

Trimerizing polypeptides

The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-&#x3b1; at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.

Antibodies to interferon-like protein Zcyto21(IL29)

Anti-zB7H6 antibody-drug conjugates

Method of using interferon-like protein ZCYTO21(IL-29) to treat hepatitis B

Method of using interferon-like potein ZCYTO20 (IL-28A) or ZCYTO22(IL-28B) to treat hepatitis B

Growing community of inventors

Seattle, WA, United States of America

Brian A Fox