Human Genome Sciences, Inc.

Bristol-myers Squibb Compnay

Brian A Dougherty

Craig A Rosen

Gil H Choi

Charles A Kunsch

Steven C Barash

Michael R Fannon

Patrick J Dillon

Daniel B Davison

Ying-Kai Wang

Mengping Liu

Matthew D Healy

Charles E Mazzucco

Trina Maurice

Kin S Lam

Wenying Li

Sandra J Hofstead

Zizhuo Xing

Christopher L Steele

Yijun Chen

Patrick J Dillion

Patrick S Dillon

The present invention provides polynucleotide sequences of the genome of, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

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The present invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used for drug screening.

Essential fungal polypeptide, CaYDR341c, and methods of use thereof

The presnt invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used for drug screening.

Essential fungal polynucleotides, polypeptides, and methods of use

Essential fungal CaYLR100w polypeptides, and methods of use

Isolated nucleic acid and amino acid sequences for phenylalanine aminomutase enzyme and methods for purifying this enzyme are provided. Methods for altering biosynthesis of compounds in plant cell cultures are also provided. In particular, methods for altering production of taxanes and taxane-related compounds are provided.

Compositions and methods for altering biosynthesis of taxanes and taxane-related compounds

The present invention relates to novel vaccines for the prevention or attenuation of infection byThe invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides ofAntigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.

Streptococcus pneumoniae SP036 polynucleotides, polypeptides, antigens and vaccines

The present invention relates to novel vaccines for the prevention or attenuation of infection byThe invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides ofAntigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detectingnucleic acids, polypeptides and antibodies in a biological sample.

Streptococcus pneumoniae SP042 polynucleotides

The present invention relates to novel vaccines for the prevention or attenuation of infection by. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detectingnucleic acids, polypeptides and antibodies in a biological sample.

Streptococcus pneumoniae SP036 polynucleotides

The present invention relates to novel vaccines for the prevention or attenuation of infection by . The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of . Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.

Streptococcus pneumoniae antigens and vaccines

The present invention provides polynucleotide sequences of the genome of , polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

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Killingworth, CT, United States of America

Brian A Dougherty