Covaris, Inc.

Millipore Corporation

Koninklijke Philips Corporation N.v.

Hewlett-packard Company

Agilent Technologies, Inc.

Brevard S Garrison

James A Laugharn, Jr

Douglas A Yates

Robert Mcknight

Michael G Verga

Julie A Beberman

Matthew Mooney

Benjamin M Herrick

Daniel A Silber

Walter Patrick Kelly, Jr

Alec Rooney

Matthew A Keary

William D Obendorf

Susan Williams

Marienne Moro Sanders

This invention relates to systems and methods for applying acoustic energy to a sample. According to one aspect of the invention, a system comprises a housing, a chamber for receiving the sample, an acoustic energy source for providing a focused acoustic field to the sample according to a treatment protocol, a processor for determining the treatment protocol, a sensor for detecting information about the sample, and a user interface for communicating with a user.

Methods and apparatus for treating samples with acoustic energy

The present invention provides systems, methods, and devices for using acoustic energy.

Methods and systems for modulating acoustic energy delivery

Acoustic energy is used to control motion in a fluid. According to one embodiment, the invention directs acoustic energy at selected naturally occurring nucleation features to control motion in the fluid. In another embodiment, the invention provides focussed or unfocussed acoustic energy to selectively placed nucleation features to control fluid motion. According to one embodiment, the invention includes an acoustic source, a controller for controlling operation of the acoustic source, and one or more nucleation features located proximate to or in the fluid to be controlled.

Method and apparatus for acoustically controlling liquid solutions in microfluidic devices

The present invention provides systems, methods, and devices for using acoustic energy. In some embodiments, a fluid bath may be provided in the system where the fluid bath quality may be monitored using acoustic energy. An assessment of fluid bath quality can be determined through a comparison that is made of an initial power signal of the acoustic energy with a reflected power signal of the acoustic energy.

Methods and systems for automated compound management and sample preparation using acoustic energy. In some embodiments, acoustic energy may be transmitted through a medium and a solid or semi-solid layer that is disposed adjacent to the vessel. Both the medium and the solid or semi-solid layer may couple acoustic energy from an acoustic energy source to a focal zone in close proximity to the sample in the vessel.

Methods and systems for processing samples using acoustic energy

Apparatus and methods are disclosed for treating a sample by selectively controlling sonic energy and/or selectively controlling the location of the sample relative to the sonic energy.

Apparatus and methods for controlling sonic treatment

The invention, in various embodiments, provides systems, methods and devices relating to processing a sample. Aspects presented herein relate to collecting, stabilizing, pulverizing, fragmenting, and/or analyzing biological and non-biological sample specimens. Before constituents of sample specimens are analyzed, the sample specimens may be fragmented into a plurality of smaller specimens. Such smaller specimens may then be stored, analyzed, or further processed.

Apparatus for sample preparation

Flexible sample vessel

The invention, in various embodiments, provides systems, methods and devices relating to processing a sample. A vessel is described for containing a sample. The vessel includes a reversibly sealable chamber for containing the sample which has a flexible portion to allow the vessel to deform nondestructively in response to a mechanical impact to fragment the sample. In certain embodiments the vessel may include a port for reversibly engaging with a second vessel to enable transfer of material between the two vessels while maintaining a barrier between the sample and an external environment. The vessel may be exposed to mechanical impacts of various energies and at various temperatures, and the internal surface of the structural barrier of the vessel may be treated with various chemical agents to maintain integrity of the sample.

Growing community of inventors

Reading, MA, United States of America

Brevard S Garrison