Novo Nordisk A/s

Brett Watson

Rolf Hohlweg

Jesper F Lau

Peter Madsen

Knud Erik Andersen

Tine Krogh Jo Slashedrgensen

Michael Ankersen

Thomas Kruse Hansen

Zdenek Polivka

Bernd Peschke

Kjeld Madsen

Alexandra Silhankova

Behrend Friedrich Lundt

Otylie Konigova

Vladimir Valenta

Martina Kovandova

Christain Thomsen

Compounds of peptide mimetic nature having the general formula Iwherein a and b are independently 1 or 2, Rand Rare independently H or Calkyl, G and J are independently, inter alia, aromats, and D and E are independently several different groups are growth hormone secretagogous with improved bioavailability.

Compounds with growth hormone releasing properties

The present invention relates to the use of small organic compounds acting as opioid receptor ligands for the treatment of vasomotor disturbances. In particular the present invention relates to the use of triaza-spiro compounds of formula

1,3,8-triazaspiro&lsqb;4.5&rsqb;decanones with high affinity for opioid receptor subtypes

The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for the treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.

1,4-disubstituted piperazines

Compounds of peptide mimetic nature having the general formula I ##STR1## wherein a and b are independently 1 or 2, R.sup.1 and R.sup.2 are independently H or C.sub.1-6 alkyl, G and J are independently, inter alia, aromats, and D and E are independently several different groups are growth hormone secretagogous with improved bioavailability.

The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for the treatment of indications caused by or related to the secretion and circulation of insulin antagonizing peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.

Growing community of inventors

Vaerloese, Denmark

Brett Watson