Bristol-myers Squibb Compnay

Brett T Watson

Katherine S Takaki

George N Karageorge

Joseph P Yevich

Graham S Poindexter

Michael Frederick Parker

Daniel J Keavy

James R Epperson

Astrid A Ortiz

Marc A Bruce

Karen L Leboulluec

A series of pyridinyl tri-substituted benzamide derivatives of general structure ##STR1## wherein the symbols R.sup.1, R.sup.2, X and n are described in detail in the specification, are useful as anticonvulsants agents.

Anticonvulsant pyridinyl benzamide derivatives

Novel substituted fluorene compunds of Formula I are active as melatonergic agents: ##STR1## wherein: X=H, halogen, OH or OZ;

Ethylamido fluorenes and improved method of making same

Novel substituted carbazole compounds of Formula I are active as melatonergic agents: ##STR1## wherein: R.sub.1 is C(O)R.sub.3 or SO.sub.2 R.sub.4 ;

Ethylamino carbazole melatonergic agents

New melatonergic agents are phenyl alkanyl or phenyl alkyl substituted carboxamides and ureas of Formula I: ##STR1## wherein: R.sub.1 =C.sub.1-3 alkyl, allyl, C.sub.3-6 cycloalkyl substituted C.sub.1-4 alkyl;

Melatonergic agents

Certain tetralinyl- and indanyl-ethylamides are useful central nervous system agents.

Tetralinyl-and indanyl-ethylamides

New central nervous system agents conform to formula I: ##STR1## wherein R=H or C.sub.1-4 alkoxy;

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Vaerloese, Denmark

Brett T Watson