Illumina Corporation

Other

Brett M Ellman

Aaron Jones

David Louis Heiner

Michal Lebl

Mark J Nibbe

Steve Fambro

Steve R Burgett

Steven P Fambro

Disclosed herein are methods of method of making a substrate for performing a chemical synthesis reaction.

Methods of forming and using a solid-phase support

Described is a system and method for synthesizing polymeric molecules such as oligonucleotides and polypeptides. The system is capable of continuously synthesizing molecules by providing an array of reaction sites and an array of stations for carrying out synthetic manipulations. The reaction sites in the former array can be placed in a fixed order and at fixed intervals relative to each other. Similarly, the stations can be placed in a fixed order and at fixed intervals relative to each other. The two arrays can be moved relative to each other such that the stations carry out desired steps of a reaction scheme at each reaction site. The relative locations of the stations and the schedule for the relative movement can correlate with the order and duration of reaction steps in the reaction scheme such that once a reaction site has completed a cycle of interacting with the full array of stations then the reaction scheme is complete.

Continuous polymer synthesizer

A method of forming a solid-phase support, the method including the steps of providing a substrate having a reaction vessel, dispensing a particle in the reaction vessel, and permanently bonding the particle in the substrate within the reaction vessel. The particle may include a microbead. The particle may include controlled pore glass. A method of synthesis is also disclosed that includes including the steps of providing a solid-phase support including a particle embedded to the substrate adjacent a surface of substrate, the particle being functionalized to covalently attach an intermediate compound of a synthetic reaction, dispensing a liquid including a reagent to the solid-phase support to effect the synthetic reaction, and removing the liquid from the solid-phase support by centrifugation, whereby the intermediate compound remains attached to the substrate by the particle.

Method of forming and using solid-phase support

The invention provides an apparatus and method for transferring a plurality of samples from an array of source sample locations to an array of destination sample locations. An apparatus or method of the invention are useful for reformatting samples in cases where the array of source sample locations differs in shape or orientation from the array of destination sample locations. The invention can be used to transfer fluid samples in the absence of an externally applied force. Because active automation is not required for transferring samples, the invention provides the advantage of a compact and efficient format for liquid handling.

Apparatus and methods for reformatting liquid samples

A wax traction pad. A support sheet is coated on the top side by a layer of traction wax. A adhesive layer coats the bottom side. In a preferred embodiment the support sheet is paper printed with a design, drawing or photograph of interest to surfers and laminated with clear plastic laminate and the bottom layer is a sticky wax. The pad is very easily applied to surfboards and is easily removed when removal is desired.

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Cardiff, CA, United States of America

Brett M Ellman