Iris International, Inc.

Drawbridge Health, Inc.

University of California

Pharmaco-Kinesis Corporation

Sensor Kinesis Corporation

Other

Shachar, Yehoshua

Chen, Thomas

Farkas, Leslie

Chan, Herwin

Jordan, Brett

Zimmerman, Kyle

Wu, Winston

Luboff, Paladin

Brett LeBeau Jordan

Bart Jan Wanders

Dagmar Beyerlein

Alicia Jackson

Kara Juneau

Masao Drexel

Thomas C Chen

Yehoshua Shachar

Gregory A Farrell

Thomas H Adams

Warren Groner

Winston Wu

Kyle Zimmerman

Herwin Chan

Leslie Farkas

Paladin Luboff

William J Kaiser

Xiaodong Zhao

Eric Chapoulaud

Jack Cremins

Maxim A Batalin

Carol Quon

Alexander A Bui

Bruce H Dobkin

Xiaoyu Xu

Seth Thomas

Lawrence Au

John Stevenson Patrick

David Patrick Stringer

Katalin Gera Myrick

Thomas Chen

Particles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. A contrast pattern for autofocusing is provided on the flowcell, for example at an edge of a rear illumination opening. The image processor assesses focus accuracy from pixel data contrast. A positioning motor moves the microscope and/or flowcell along the optical axis for autofocusing on the contrast pattern target. The processor then displaces microscope and flowcell by a known distance between the contrast pattern and the sample stream, thus focusing on the sample stream. Blood cell images are collected from that position until autofocus is reinitiated, periodically, by input signal, or when detecting temperature changes or focus inaccuracy in the image data.

Autofocus systems and methods for particle analysis in blood samples

Device for sample collection

Disclosed herein are devices, apparatus, systems, methods and kits for collecting and storing a fluid sample from a subject. A device for collecting the fluid sample can include a housing comprising a recess having an opening, a vacuum chamber in the housing and in fluidic communication with the recess, and one or more piercing elements that are extendable through the opening to penetrate skin of the subject. The vacuum chamber can be configured for having a vacuum that draws the skin into the recess. The recess can be configured having a size or shape that enables an increased volume of the fluid sample to be accumulated in the skin drawn into the recess.

Devices for collecting biological samples

Carriers for storage and transport of biological samples

Cartridge assemblies for storing biological samples

The present disclosure relates to apparatus, systems, compositions, and methods for analyzing a sample containing particles. A particle imaging system or analyzer can include a flowcell through which a urine sample containing particles is caused to flow, and a high optical resolution imaging device which captures images for image analysis. A contrast pattern for autofocusing is provided on the flowcell. The image processor assesses focus accuracy from pixel data contrast. A positioning motor moves the microscope and/or flowcell along the optical axis for autofocusing on the contrast pattern target. The processor then displaces microscope and flowcell by a known distance between the contrast pattern and the sample stream, thus focusing on the sample stream. Cell or particle images are collected from that position until autofocus is reinitiated, periodically, by input signal, or when detecting temperature changes or focus inaccuracy in the image data.

Flowcell, sheath fluid, and autofocus systems and methods for particle analysis in urine samples

Devices, systems, and methods for sample collection

A portable beverage dispensing system is disclosed. The portable beverage dispensing system includes a reservoir container with an internal volume for holding a beverage. The beverage dispensing system also includes a pressure unit accessory and a dispensing mechanism accessory that detachably and interchangeably attached to accessory attachments on the reservoir container that are in fluid communication with the internal volume of the reservoir container. The pressure unit accessory includes a pressure regulator and a removable gas canister for pressurizing the reservoir container and dispensing the beverage through the dispensing mechanism accessory.

Pressurized counter-top beverage dispensing system

An exercise system comprising: an exercise cycle comprising a crank, wherein the crank is configured to be rotated by a user; and a sensing unit coupled to the exercise cycle, wherein the sensing unit is configured to sense information related to at least one crank measurement and to transmit the information related to the at least one crank measurement to a remote device via wireless communication. In some embodiments, the remote device is a mobile device. In some embodiments, the at least one crank measurement comprises a rotational speed of the crank or a force applied to the crank. The remote device can display information related to use of the exercise cycle based on the information received from the exercise cycle.

Exercise promotion, measurement, and monitoring system

Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer. Embodiments also encompass systems, compositions, and methods for analyzing a sample containing particles. Parrticles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed, for example using certain focusing techniques, into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. Blood cell images can be collected and analyzed using dynamic range extension processes and systems.

Hematology systems and methods

Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer. Embodiments also encompass systems, compositions, and methods for analyzing a sample containing particles. Particles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed, for example using certain focusing techniques, into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. Blood cell images can be collected and analyzed using dynamic range extension processes and systems.

Growing community of inventors

San Francisco, CA, United States of America

Brett LeBeau Jordan