The General Hospital Corporation

Massachusetts Institute of Technology

Infraredx, Inc.

University of Colorado

Boston University

Harvard College

Nanyang Technological University

The Uab Research Foundation

Massachusetts Eye and Ear Infirmary

The General Hospital Corproation

Brett Eugene Bouma

Guillermo J Tearney

Milen Stefanov Shishkov

Dvir Yelin

Benjamin J Vakoc

Seok-Hyun Yun

Johannes Fitzgerald De Boer

Joseph A Gardecki

Nicusor V Iftimia

Linbo Liu

James G Fujimoto

Dongkyun Kang

Norman S Nishioka

Wang-Yuhl Oh

Andres Zuluaga

Seok-Hyun (Andy) Yun

Wang-Yuhl (William) Oh

Simon M Furnish

Jing Tang

Farouc Amin Jaffer

S Eric Ryan

Hongki Yoo

Eric Arthur Swanson

Roman Shubochkin

Melissa Suter

Mark Brezinski

Stephen A Boppart

Theodore Morse

Michalina Gora

Robert R McLeod

Robert H Webb

Eric J Sorscher

Kengyeh Ken Chu

Steven Mark Rowe

Robert Carruth

Kevin Gallagher

Constantinos Pitris

Johannes deBoer

John A Evans

Jenny Sauk

Christopher Max Colice

Jinyong Ha

Moon Gu Lee

Nima Tabatabaei

Bradford James Diephuis

Eric James Wilsterman

Gregory Andrew Dierksen

Adrien E Desjardins

George M Whitesides

Raymond C Chan

Seemantini K Nadkarni

Eman Namati

Tao Wu

John Rosowski

Wang Yuhl Oh

Adrien Desjardins

Saumil N Merchant

Xinyu Liu

Kevin Woods

William C Warger, Ii

Martha Pitman

Tearney J Guillermo

Martin Villiger

Qiaozhou Xiong

Nanshuo Wang

Millen Shishkov

Christine Fleming

Mark A Griffin

Gary J Tearney

Simon C Schlachter

Rames Martinez

Ben Vakoc

Jonathan Jay Rosen

Reza Motaghiannezam

Jing Yuan

Seok-Yun Yun

Dongyun Kang

S M Reza Motaghiannezam

Jason T Motz

William Oh

Johannes Deboer

Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.

Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof

Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. At least one second radiation can be received from the portion which is based on the first radiation. Based on an interaction between the optical arrangement and the first radiation and/or the second radiation, the optical arrangement can have a first transfer function. Further, it is possible to forward at least one third radiation to the portion through such optical arrangement (or through another optical arrangement), and receive at least one fourth radiation from the portion which is based on the third radiation. Based on an interaction between the optical arrangement (or the other optical arrangement) and the third radiation and/or the fourth radiation, the optical arrangement (or the other optical arrangement) can have a second transfer function. The first transfer function can be at least partially different from the second transfer function. The data can be generated based on the second and fourth radiations.

Optical fiber, light tunnel, and lens which provide extended focal depth of at least one anatomical structure at a particular resolution

Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions

An exemplary apparatus for obtaining data for at least one portion within at least one luminal or hollow sample can be provided. For example, the apparatus can include a first optical arrangement configured to transceive at least one electromagnetic radiation to and from the portion(s). The apparatus can also include a wavelength dispersive second arrangement, which can be configured to disperse the electromagnetic radiation(s). A housing can be provided with a shape of a pill, and enclosing the first and second arrangements.

Apparatus, device and method for capsule microscopy

Exemplary embodiments of apparatus, system and method can be provided to measure a flow of fluid within an anatomical structure. For example, it is possible to use at least one first probe arrangement structured to be insertable into a vessel and configured to direct at least one radiation to at least one portion of the anatomical structure. Further, it is possible to provide at least one second arrangement which configured to detect an interference between a first radiation provided from the fluid via the probe arrangement and second a second radiation provided from a reference path as a function of wavelength thereof. Further, at least one third arrangement can be provided which is configured to determine at least one characteristic of the fluid as a function of the interference.

Apparatus, systems and methods for measuring flow and pressure within a vessel

A method for determining a retardance of a layer of a sample. The method includes: transmitting a first portion of a polarized light to a sample arm of an optical system and a second portion of the polarized light to a reference arm of the optical system; combining first return light returned from the sample arm and second return light from the reference arm; detecting, using a detector, the combined light along a first polarization state and a second polarization state to produce polarization data, the second polarization state being different from the first polarization state; determining, using a processor coupled to the detector, polarization states of light returning from upper and lower surfaces of a layer of the sample based on detecting the combined light; and determining, using the processor, a retardance of the layer of the sample based on the determined polarization states.

Method and apparatus for measuring depth-resolved tissue birefringence using single input state polarization sensitive optical coherence tomography

Exemplary apparatus and method can be provided for obtaining data regarding a plurality of samples. For example, using at least one arrangement, it is possible to receive interferometric information that is based on radiations provided from a reference and the samples that are provided in respective chambers. Alternatively and/or in addition, based on the interferometric information, it is possible to discriminate between agents to identify a particular agent that affects a particular function within at least one of the samples.

Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures

Exemplary embodiments of apparatus and method according to the present disclosure are provided. For example, an apparatus for providing electromagnetic radiation to a structure can be provided. The exemplary apparatus can include a first arrangement having at least two wave-guides which can be configured to provide there through at least two respective electro-magnetic radiations with at least partially different wavelengths from one another. The exemplary apparatus can also include a dispersive second arrangement structured to receive the electro-magnetic radiations and forward at least two dispersed radiations associated with the respective electro-magnetic radiations to at least one section of the structure. The wave-guide(s) can be structured and/or spatially arranged with respect to the dispersive arrangement to facilitate at least partially overlap of the dispersed radiations on the structure. In addition, another arrangement can be provided which can include at least two further wave-guides which can be configured to receive the electro-magnetic radiations from the dispersive arrangement. Each of the further wave-guides can be structured and/or spatially arranged with respect to the dispersive arrangement to facilitate a receipt of a different one of the such electro-magnetic radiations as a function of wavelengths thereof.

Apparatus and method for facilitating at least partial overlap of dispersed ration on at least one sample

Apparatus and method according to an exemplary embodiment of the present invention can be provided for analyzing tissue. For example, the apparatus can include at least one first arrangement configured to illuminate at least one anatomical structure with at least one of at least one electro-magnetic radiation. The apparatus can also include at least one second arrangement that may include at least two wave-guiding arrangements associated with one another that are configured to receive a further electro-magnetic radiation reflected from the tissue and transmit at least one speckle pattern associated with the further electro-magnetic radiation. The wave-guiding arrangements may be structured so as to reduce crosstalk therebetween.

System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque

Light tunnel and lens which provide extended focal depth of at least one anatomical structure at a particular resolution

An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.

Process and apparatus for a wavelength tuning source

According one exemplary embodiment of the present invention, method and system can be provided for applying a laser radiation to at least one portion of a biological structure. For example, a beam of the laser radiation can be provided to the portion, whereas a cross-sectional area of the beam is at most about 1/10th of an entire area of the at least one portion. The beam can be applied to the portion (a) based on a predetermined pattern, (b) while modulating a wavelength of the laser radiation, and/or (c) while monitoring a depth of the application of the laser radiation.

Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures

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Quincy, MA, United States of America

Brett Eugene Bouma