University of Utah Research Foundation

Navigen, Inc.

The United States Of America—air Force

Brett D Welch

Michael S Kay

Debra Muir Eckert

Michael Thomas Jacobsen

Matthew T Weinstock

Rena McKinnon

James Nicholas Francis

Tracy R Clinton

Disclosed herein are compositions and methods for inhibiting respiratory syncytial virus (RSV) entry into a host cell. Also provided herein are methods of identifying a peptide that interacts with the N-trimer of RSV F protein.

Compositions and methods related to inhibition of respiratory syncytial virus entry

Disclosed are compositions and methods for inhibiting viral entry.

Methods and compositions related to inhibition of viral entry

Disclosed are D-peptide compositions and methods for inhibiting HIV entry into host cells.

D-peptide inhibitors of HIV entry and methods of use

is a highly lethal filovirus that causes hemorrhagic fever in humans and non-human primates. With no approved treatments or preventatives, the development of an anti-therapy to protect against natural infections and potential weaponization is an urgent unmet global health need. The design, biophysical characterization, and validation of peptide mimics of theN-trimer ('N-trimer mimics') are described herein.

Growing community of inventors

Salt Lake City, UT, United States of America

Brett D Welch