Merck Sharp + Dohme Corp.

Brett A Hopkins

Hua Zhou

Yongxin Han

Hongjun Zhang

David L Sloman

Derun Li

Nunzio Sciammetta

Yongqi Deng

Catherine M White

Xavier Fradera

Kun Liu

Abdelghani Achab

Craig R Gibeau

Meredeth Ann McGowan

Meredeth A Mcgowan

Alexander Pasternak

Xianhai Huang

Wensheng Yu

Ping Liu

Phieng Siliphaivanh

Liangqin Guo

Andrew M Haidle

Charles A Lesburg

Qinglin Pu

Min Lu

David Jonathan Bennett

Brandon D Cash

Matthew A Larsen

Indu T Bharathan

Xin Yan

Wenlang Fu

Sulagna Sanyal

George Madalin Giambasu

Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as IL4I1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for IL4I1-related diseases.

IL4I1 inhibitors and methods of use

Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

Substituted tetrahydroquinolin compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors

Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: Formula (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

Substituted tricyclic compounds as indoleamine 2,3-dioxygenase inhibitors

Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors

Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof:  Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

Growing community of inventors

Brownsburg, IN, United States of America

Brett A Hopkins