Arizona State University

Banner Health

Unversität Zürich

Eidgenossische Technische Hochschule Zurich

Brent Vernon

Donald Leo Elbert

Ronald Schoenmakers

Mehdi Nikkhah

Derek J Overstreet

Alex McLaren

Matthias Lütolf

Ryan McLemore

Alison Pratt

Nicola Tirelli

Jeffrey A Hubbel

A hydrogel (I), comprising a polymer backbone wherein an aqueous solution of the hydrogel comprises a first lower critical solution temperature, and wherein the hydrogel is configured to be converted in vivo into a modified hydrogel, and wherein an aqueous solution of the modified hydrogel comprises a second lower critical solution temperature, and wherein the second lower critical solution temperature is greater than the first lower critical solution temperature.

In situ forming hydrogel and method using same

The present invention provides a temperature-responsive dual-gelling hydrogel comprising a plurality of hydrogel polymers and a polymer cross-linking moiety, wherein the LCST of the hydrogel polymers is less than 37&#xb0; C., and the polymer cross-linking moiety is capable of chemically cross linking to the hydrogel polymers to form a polymer matrix.

Injectable cell-laden biohybrid hydrogels for cardiac regeneration and related applications

Growing community of inventors

Queen Creek, AZ, United States of America

Brent Vernon