Allosource

Ferring B.v.

Brookhaven Science Associates, Lcc

Dentsply International Inc.

Biosurface Engineering Technologies, Inc.

Sulzer Innotec Ag

Sulzer Biologics, Inc.

S&ugrave;lzer Biologics Inc.

Dentsply Sirona Inc.

Brent Lee Atkinson

Paul O Zamora

Xinhua Lin

Louis A Pena

Reginald L Stilwell

Adrian C Samaniego

James John Benedict

Yaling Shi

Brian Dittman

Tracey S Hanks

John Paul Ranieri

Donald Chickering

Pedro Bittmann

Marsha L Whitney

Katherine Suzanne Walline

A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analogue is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.

Composition and method for delivery of BMP-2 amplifier/co-activator for enhancement of osteogenesis

The present invention provides compositions for treating soft tissue injuries comprising a collagen matrix and mesenchymal stem cells adhered to the collagen matrix. Methods of making and using compositions comprising a collagen matrix and mesenchymal stem cells adhered to the collagen matrix are also provided.

Cell repopulated collagen matrix for soft tissue repair and regeneration

Composition and method for delivery of BMP-2 amplifler/co-activator for enhancement of osteogenesis

A composition comprising a synthetic growth factor analog comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analog is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.

Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.

Flowable matrix compositions and methods

A bone repair material is described that is of putty-like consistency, particularly useful for repairing dental bony defects such as those caused by bone loss resulting from moderate or severe periodontitis, augmenting of bony defects of the alveolar ridge, filling tooth extraction sites, or sinus elevation grafting. The repair material includes a porous, resorbable particulate that is bone-derived or derived from bone-like hydroxyapatite or synthetic hydroxyapatite; and, a resorbable carrier, such as high molecular weight polysaccharides, such as hyaluronic acid. A high concentration of particulate in the putty enhances bone repair and requires a high concentration of carrier to retain the putty at the defect site. For a particulate density of about 1.2 g/cc such as PEPGEN P-15&#xae; Bone Graft, a preferred formulation comprises about 55% percent by weight of the putty suspended in a hyaluronic acid gel of about 1.4&#xd7;10daltons molecular weight and a final concentration of about 56 mg/cc which material adheres to a bony periodontal defect and does not excessively expand or migrate from the defect when held in place by a conventional flap closure.

Bone repair putty

Composition comprising BMP-2 amplifier/co-activator for enhancement of osteogenesis

Growing community of inventors

Highlands Ranch, CO, United States of America

Brent Lee Atkinson