Merial Limited

Avista Pharma Solutions, Inc.

Advitech Advisory and Technologies Sa

Boehringer Ingelheim Animal Health USA Inc.

Brent Christopher Beck

Loic Patrick Le Hir De Fallois

Hyoung Ik Lee

Douglas Edward Wilkinson

Jason Daniel Speake

Joe B Perales

Bharathi Pandi

Mark David Soll

Mark Soll

Scot Kevin Huber

Robert Toms Jacobs

Joseph Alexander Moore, Iii

Jennifer Freeman

Loïc Patrick Le Hir De Fallois

Hao Liu

Ilaria Ferrando

Jessica Marie Sligar

Hyoung Lk Lee

Loic Patrick Le Hir De Falois

The present disclosure describes a synthetic process and novel intermediates related to spirocyclic azetidenyl-isobenzofuran derivatives having an isothiazoline moiety, which are useful as antiparasitics.

Synthetic process and intermediates

The present disclosure describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the disclosure have activity as prostaglandin EP4 receptor antagonists, and are useful in the treatment or alleviation of pain and inflammation and other inflammation-associated disorders, such as arthritis, treating or preventing disorders or medical conditions selected from pain, inflammatory diseases and the like. Also described herein are methods of treating pain by administering the compounds of the disclosure, which are EP4 receptor antagonists.

Chemical compounds

The present invention relates to a process for the preparation of rucaparib; the invention also refers to novel intermediates of synthesis as well as their use in the preparation of i.a. rucaparib.

Process for the preparation of rucaparib and novel synthesis intermediates

The present invention relates to novel dihydroazole of formula (I) and salts thereof: Wherein R, A, A, G, X and Y are as defined in the description, compositions thereof, processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.

Antiparisitic dihydroazole compounds and compositions comprising same

The invention relates to 1,2,4-thiadiazole derivatives and their use to treat parasites.

Antiparasitic compounds

The present invention relates to novel aryloazol-2-yl-cyanoethylamino derivatives substantially enriched in an enantiomer of formula (I): and compounds of formula (IH) wherein R, R, R, R, R, R, R, R, R, P, Q, V, W, X, Y, Z and a are as defined in the description, compositions thereof, processes for their preparation and their uses as pesticides.

Enantiomerically enriched aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof

Growing community of inventors

Apex, NC, United States of America

Brent Christopher Beck