Tissuegen, Inc.

The University of Texas System

Ethicon, Gmbh

Brent B Crow

Kevin D Nelson

Nickolas B Griffin

Paul R Sood

Jennifer Seifert

Alpeshkumar P Patel

Paul A Hubbard

Jeffrey Mendel Gross

Lev Drubetsky

Alexander Naimagon

William L D'Agostino

Rui Avelar

Paula J Taylor

William L D'agostino

Kevin Don Nelson

Jeffrey M Gross

A composition includes a target pharmaceutical or biological agent, a solution containing the target pharmaceutical or biological agent, and substrate that is soluble in the solution. The substrate is capable of being solidified via a solidification process and the solidification process causes the substrate to become physically or chemically cross-linked, vitrified, or crystallized. As a result of the solidification process, particles are formed. The target pharmaceutical or biological agent within the solution retains proper conformation to ultimately produce a desired effect.

Methods and compositions for maintaining the conformation and structural integrity of biomolecules

A drug-eluting self-retaining suture comprises a filament, a plurality of retainers, and a drug impregnated in or coated on the filament. The shape and distribution of retainers modifies the in vivo release kinetics of the drug. The drug release kinetics may be modified uniformly or region by region. The self-retaining suture may for example be used for reattaching severed nerves and release nerve growth factor or other regeneration accelerating agents into the region of the nerve injury.

Drug-eluting self-retaining sutures and methods relating thereto

The invention relates to a helical coil comprising multiple reversing sense helical coil units that are capable of drug elution, come in lengths appropriate for long, diffuse lesions, have the ability to have a step-wise tapering diameter, and provide all the benefits of a small closed cell stent design while maintaining high flexibility, high radial force and crush resistance due to an underlying helical coil.

Self-expanding medical device

The present invention relates to fiber compositions comprising gels or hydrogels. The invention further relates to the composition of a gel or hydrogel loaded biodegradable fiber and methods of fabricating such fibers. The present invention further provides tissue engineering and drug-delivery compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The invention also relates to methods of manipulating the rate of therapeutic agent release by changing both the biodegradable polymer properties as well as altering the properties of the incorporated gel or hydrogel.

Drug releasing biodegradable fiber for delivery of therapeutics

Growing community of inventors

Grand Prairie, TX, United States of America

Brent B Crow