University of California

Other

Brent A Dethlefs

George A Gutman

Kanianthara G Chandy

Stephan Grissmer

Michael D Cahalan

Shengwen Li

William Gunter Loudon

Alan L Goldin

John J Wasmuth

Sanjiu Ghanshani

An organotypic slice and a method of preparing an organotypic slice from a central nervous system tissue, wherein the organotypic slice comprises a brain slice obtained from a brain wherein mature synapses have not been established and the organotypic slice is seeded with a population of stem cells; wherein the organotypic slice has enhanced viability as compared to an organotypic slice comprising a similar brain slice not seeded with a population of stem cells.

Organotypic slices of the central nervous system

This disclosure relates to the n K.sup.+ channel expression product of the MK3 gene or a functionally bioactive equivalent thereof and its uses, particulary in combination with identifying immune responses and materials modulating or blocking same.

Assay, methods and products based on n K.sup.+  channel expression

This disclosure relates to the general diagnosis and treatment of autoimmune diseases with materials identified in assays based upon the finding herein that such diseases manifest by elevated numbers of type l K.sup.+ channels in abnormal CD4.sup.- CD8.sup.- T cells.

Assay for and treatment of autoimmune diseases

Growing community of inventors

Laguna Niguel, CA, United States of America

Brent A Dethlefs