Vanderbilt University

Brendan Dutter

Gary Allen Sulikowski

Alex Gregory Waterson

Charles David Weaver

Eric P Skaar

Paul R Reid

Matthew Surdel

Provided are novel rhodol-based compounds, the preparation method thereof, and use thereof in Tlflux assays. The fluorescent thallium ion sensor compounds have a rhodol fluorophore attached to an amino dicarboxylic acid metal binding moiety. The compounds are prepared in the 'pro-dye' form, with the rhodol oxygen and the carboxylic acids of the metal binding unit masked by protecting groups. The disclosed compounds may be used as more red-shifted and less pH-sensitive variants of Thallos.

Rhodol-based thallium sensors for high-throughput screening of potassium channels

A method for treating a microbial infection involves administering an effective amount of a compound of the formula: wherein Ris H, alkyl, aryl, heteroaryl, Ris H, halogen, alkyl, aryl, heteroaryl, Ris H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, Ris H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, Ris H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, Ris H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, Ris H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, Ris &#x2014;CR, O, S, wherein Rand R, Rand R, Rand R, Rand Rcan cyclize forming a 3-10 member ring comprising C, O, S, and/or N optionally substituted with one or more R; and administering light therapy, such as a photodynamic therapy (PDT) light source.

Methods for use of small molecule activators of hem-Y / protoporphyrinogen oxidase (PPO)

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Nashville, TN, United States of America

Brendan Dutter