Millennium Pharmaceuticals Limited

Entasis Therapeutics, Inc.

Brendan Chen

Paul E Fleming

Zhan Shi

John Charles Reader

Neil Bifulco

Jeffrey P Ciavarri

Bolin Geng

Hoan Huynh

Jane F Schmidt

Thomas Francois Durand-Reville

Janelle Comita-Prevoir

Satenig Guler

Hui Xiong

Liang Zhao

Shanta Bist

Neal D Hone

Ye Wu

Daemian Dussault

Helen Mcguire

Helen McGuire

The present invention is directed to compounds which are beta-lacatamase inhibitors. The compounds and their pharmaceutically acceptable salts, are useful in combination with beta-lactam antibiotics, or alone, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes compounds according to formula (Ia): or a pharmaceutically acceptable salt thereof, wherein the values of R, R, Rand Rare described herein.

&#x3b2;-lactamase inhibitor compounds

Beta-lactamase inhibitor compounds

A heterocyclic inhibitor having the formula I, with the variables defined herein, which is useful for treating inflammatory and other physiological disorders in which PKC-theta isoform plays a role: 

2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases

Growing community of inventors

Sudbury, MA, United States of America

Brendan Chen